Results 91 to 100 of about 813,966 (259)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

The effects of inorganic nitrogen and phosphorus enrichment on herbaceous species growth of the Kimages Creek wetland (VA) [PDF]

open access: yes, 2017
Dissolved inorganic nitrogen (DIN) and dissolved inorganic phosphorus (DIP) infiltrate waterways through fertilizer application, urban stormwater runoff, and sewer infrastructure leaks.
Burton, Kristen, Neubauer, Scott C.
core   +1 more source

Potential for improvement of population diet through reformulation of commonly eaten foods [PDF]

open access: yes
Food reformulation: Reformulation of foods is considered one of the key options to achieve population nutrient goals. The compositions of many foods are modified to assist the consumer bring his or her daily diet more in line with dietary recommendations.
Hendriksen, M.   +2 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Scientific investigations in the Gulf of Mexico and Caribbean Sea during the 1974-1975 Calypso cruise, parts 1 and 2 [PDF]

open access: yes
The distribution and concentrations of the standing crop of phytoplankton and nutrient salts in the Gulf of Mexico and the Caribbean Sea were investigated to provide ground truth for correlating temperature and chlorophyll-a measurements with ...
Babai, P.   +6 more
core   +1 more source

Soil nutrient levels define herbage yield but not root biomass in a multispecies grass-legume ley [PDF]

open access: yes, 2018
The response of above- and below-ground biomass to soil nutrient availability is crucial for estimating belowground carbon input and predicting changes in soil carbon storage.
Christensen, B.T.   +2 more
core  

Decomposition of coarse woody debris in a long-term litter manipulation experiment: A focus on nutrient availability [PDF]

open access: yes, 2018
The majority of above-ground carbon in tropical forests is stored in wood, which is returned to the atmosphere during decomposition of coarse woody debris.
Gora, Evan M.   +3 more
core   +3 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Plant functional constraints on foliar N:P ratios in a tropical forest landscape [PDF]

open access: yes, 2009
Although large scale analyses of foliar N:P ratios suggest and overall pattern of P limitation in tropical forests, analyses within the biome are less indicative of a consistent pattern of nutrient limitation.
Carlos A. Sierra
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

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