Results 101 to 110 of about 813,966 (259)

Processes controlling the quantities of biogenic materials in lakes and reservoirs subject to cultural eutrophication [PDF]

, 1980
The processes which control the growth, composition, succession and loss from suspension of phytoplankton algae are briefly reviewed, with special reference to function in eutrophic reservoir systems.
Reynolds, , C.S.
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Dynamics of Nutrient Components and Microbial Communities in Substrates During the Development of the Fruiting Bodies of Volvariella volvacea

Journal of Fungi
Cotton waste, a growth medium for Volvariella volvacea, has significant commercial and nutritional value. Under controlled environmental conditions, substrate nutrient composition and microorganisms affect the growth of V. volvacea.
Le Wang, Qin Dong, Qian Guo, Lei Zha, Lin Yang, Changxia Yu, Yan Zhao   +6 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Effect of the growing season duration of sorghum and Sudan grass hybrids on the chemical composition and digestibility of organic matter

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013
In our experimental study we used the four most commonly grown (in the Czech Republic) sorghum and Sudan grass hybrids from USA (Nutri Honey, Latte, Honey Graze, Big Kahuna) and one hybrid from Germany (Bovital). The aim of the study was to compare these
Jitka Dvořáčková, Petr Doležal, Ivo Vyskočil   +2 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Effects of fire on composition, biomass, and nutrients in oak scrub vegetation on John F. Kennedy Space Center, Florida [PDF]

Four stands of oak scrub two, four, eight, and 25 years since fire were sampled with permanent 15 m line transects. Percent cover by species was determined. Plant samples were analyzed for a variety of substances.
Hinkle, C. Ross, Schmalzer, Paul A.
core   +1 more source

Factors influencing the abundance, community composition and activity states of bacterioplankton from the tidal freshwater James River [PDF]

, 2010
Aquatic bacteria respond to changing environmental conditions through a variety of mechanisms including changes in abundance, shifts in community composition and variable activity states.
Luria, Catherine
core   +2 more sources