Results 201 to 210 of about 1,130,833 (358)

Nutrient intake and digestibility of West Africa Dwarf rams fed basal diet supplemented with multi-nutrient block

open access: yes
Thirty-five (35) West African Dwarf rams (WAD) with an average weight of 13.60+0.2 kg were used to evaluate nutrient intake and digestibility of WAD rams fed basal diet supplemented with multi-nutrient block in a Completely Randomized Design.
Abdulsalam, Sherifdeen   +6 more
core   +1 more source

Effects of capsaicin and monensin on ruminal fermentation, intake, nutrient digestibility, and ruminal dynamics of grazing bulls. [PDF]

open access: yesArch Anim Breed
Santiago MR   +11 more
europepmc   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

open access: yesAdvanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong   +14 more
wiley   +1 more source

Nutrient Intake, Nutrient Digestibility, Growth Performance, and Blood Parameters of Kacang Goats with GDF9 Genotype

open access: yes
This study aims to determine the different growth differentiation factor 9 (GDF9) genotypes in Kacang goats and their influence on the animals’ nutrient intake, digestibility, digestible nutrients, performance, and blood chemical composition. Twenty-five
Sigit Bintara   +4 more
core   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

open access: yesAdvanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng   +14 more
wiley   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

open access: yesAdvanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang   +11 more
wiley   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

open access: yesAdvanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang   +9 more
wiley   +1 more source

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