Results 61 to 70 of about 370,022 (309)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Increased uptake and accumulation of phosphorus and other nutrients by legumes enhance their bioavailability for non-legume species

Plant, Soil and Environment
Legumes are promoted in agroecosystems for their ability to fix atmospheric nitrogen (N), thereby reducing or eliminating the need for N fertilisation while also contributing N-rich organic residues, which non-legume species can subsequently utilise.
Peltier Aguiar, Margarida Arrobas, Manuel Ângelo Rodrigues   +2 more
doaj   +1 more source

Ion Exchange for Nutrient Recovery Coupled with Biosolids-Derived Biochar Pretreatment to Remove Micropollutants [PDF]

, 2018
Wastewater, especially anaerobic treatment effluent, contains high ammonia nitrogen (NH4-N) and inorganic orthophosphate (PO4-P), which necessitate additional treatment to meet stringent discharge regulations.
Avila, Anna, Kimbell, Lee K., Mayer, Brooke K., McNamara, Patrick J., Tong, Yiran   +4 more
core   +1 more source

Enhancing nutrient recovery from food waste anaerobic digestate

Bioresource Technology, 2023
The study synthesised the raw liquid fraction of digestate into a nutrient rich solid digestate through acidification whilst preventing nitrogen loss through ammonium volatilisation during evaporation. To stabilise ammonium in the digestate, it was acidified with sulphuric, nitric, and phosphoric acid to produce solid digestate with ammonium sulphate ...
James O'Connor, Bede S. Mickan, Sun K. Gurung, Kadambot H.M. Siddique, Matthias Leopold, Nanthi S. Bolan   +5 more
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Total Value of Phosphorus Recovery [PDF]

, 2016
Phosphorus (P) is a critical, geographically concentrated, nonrenewable resource necessary to support global food production. In excess (e.g., due to runoff or wastewater discharges), P is also a primary cause of eutrophication.
Baker, Lawrence A., Boyer, Treavor H., Drechsel, Pay, Gifford, Mac, Hanjra, Munir A., Mayer, Brooke K., Parameswaran, Prathap, Rittmann, Bruce E., Stoltzfus, Jared, Westerhoff, Paul   +9 more
core   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Techniques for nutrient recovery from digestate: inventory [PDF]

, 2013
Because of the historic presence of intensive livestock production and the limited amount of arable land for manure disposal, nitrate pollution in certain European areas is considerable. The European Nitrate Directive, implemented in 1991, is intended to
Accoe, Frederic, Ghekiere, Greet, Lebuf, Viooltje, Meers, Erik, Michels, Evi, Ryckaert, Bart, Van Elsacker, Sara, Vaneeckhaute, Céline   +7 more
core   +1 more source

Phosphate removal in agro-industry: pilot- and full-scale operational considerations of struvite crystallization [PDF]

, 2009
Pilot-scale struvite crystallisation tests using anaerobic effluent from potato processing industries were performed at three different plants. Two plants (P1 & P2) showed high phosphate removal efficiencies, 89 + 3% and 75 + 8%, resulting in final ...
Carballa, Marta, Derycke, Dirk, Moerman, Wim, Vandekerckhove, Andy, Verstraete, Willy   +4 more
core   +2 more sources