Results 81 to 90 of about 285,327 (262)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Low-Temperature Biochar Replacing Peat Enables Halving Nutrient Solution in Dwarf Tomato Soilless Culture

Horticulturae
Horticultural reliance on non-renewable peat faces critical sustainability challenges. Low-temperature biochar (LTB) presents a promising alternative, offering higher biochar yields and lower energy inputs compared to conventional high-temperature ...
Yuanyuan Li, Yu Meng, Peihua Zhang, Xiangyu Huang, Yuchen Che, Nannan Wu, Yifan Zhang, Yi Liu, Haibo Meng, Lin Ouyang, Dongdong Zhang   +10 more
doaj   +1 more source

Nutrient Solutions for Hydroponic Systems [PDF]

, 2012
Among factors affecting hydroponic production systems, the nutrient solution is considered to be one of the most important determining factors of crop yield and quality. This chapter aims to explain aspects related to plant nutrition and its effects on production of hydroponic crops, considering basic aspects such as nutrient solutions and their ...
Libia I., Fernando C.
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Development of a Numeric Table for Determination of the Amount of Nutrient Solution in an Infusion of Nutrient Stock Solution

Journal of Clinical Nutrition, 2009
Development of a Numeric Table for Determination of the Amount of Nutrient Solution in an Infusion of Nutrient Stock Solution Jeong Hong, M.D., Young Joo Lee, M.D., Mee Kyung Song, R.Ph., Myoung On Eun, R.Ph., Mee Hyang Kim, R.D., Youn Hee Lee, R.D., Youn Hee Ahn, R.N., Jee Yang Kim, R.N.
Jeong Hong, Young Joo Lee, Mee Kyung Song, Myoung On Eun, Mee Hyang Kim, Youn Hee Lee, Youn Hee Ahn, Jee Yang Kim   +7 more
openaire   +2 more sources

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source