Results 41 to 50 of about 153,995 (308)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Effects of Organic Fertilizer Substitution for Mineral Fertilizer on Soil Fertility, Yield, and Quality of Muskmelons

Agronomy
The excessive use of chemical fertilizers has resulted in a decline in soil quality, crop yield, and crop quality. Partial substitution of chemical fertilizers with organic fertilizers is a sustainable practice that can alleviate these issues. However, a
Zhanlonggang Yu, Bing Guo, Tao Sun, Ran Li, Zichao Zhao, Li Yao   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Effects of Different Carbon and Nitrogen Ratios on Yield, Nutritional Value, and Amino Acid Contents of Flammulina velutipes

Life
The carbon-to-nitrogen (C/N) ratio in the cultivation medium significantly influences the growth rate, vigor of mycelium, yield of fruiting bodies, and their nutritional composition.
Jiandong Han, Ruixiang Sun, Chunyan Huang, Hongyan Xie, Xia Gao, Qiang Yao, Peng Yang, Jin Li, Zhiyuan Gong   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Fulvic acid application increases rice seedlings performance under low phosphorus stress

BMC Plant Biology
Background Fulvic acid enhances plant growth and interacts synergistically with phosphate fertilizer to alleviate the agricultural production problem of low phosphorus fertilizer utilization efficiency.
Xiaomeng Lv, Qingchao Li, Xuan Deng, Shitao Ding, Ruibo Sun, Shunquan Chen, Wenjing Yun, Changrong Dai, Bingbing Luo   +8 more
doaj   +1 more source

The Carbon Footprint and Influencing Factors of the Main Grain Crops in the North China Plain

Agronomy
The North China Plain (NCP) serves as a critical grain-producing region in China, playing a pivotal role in ensuring the nation’s food security. A comprehensive analysis of the carbon footprint (CF) related to the cultivation of major grain crops within ...
Tao Sun, Hongjie Li, Congxin Wang, Ran Li, Zichao Zhao, Bing Guo, Li Yao, Xinhao Gao   +7 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Soil Organic Carbon and Nitrogen Fractions as Affected by the Co-Incorporation of Rice and Chinese Milk Vetch Residues in Paddy Fields

Agronomy
Co-incorporating rice straw and Chinese milk vetch (CMV) residues can enhance soil organic carbon (SOC) sequestration and productivity. However, limited information exists regarding its effects on SOC and nitrogen (N) pools as well as the sustainability ...
Yuanfeng Hao, Zhi Wang, Shanshan Wang, Chunyang Gu, Hongjuan Lu, Zonglin Shi, Shuo Li   +6 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source