Results 61 to 70 of about 140,189 (262)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Achieving the goal of the “4‰ initiative” and agricultural sustainability by co-incorporating rice straw and Chinese milk vetch for rice production in southern China

Geoderma
The co-incorporation of rice straw (RS) and Chinese milk vetch (CMV) has been suggested as an optimized agronomic management strategy to improve soil organic carbon (SOC) storage and agricultural sustainability.
Yu Zhang, Wangwang Zhang, Fei Xu, Yuhang Qin, Hao Chen, Yuhong Wu, Shuo Li   +6 more
doaj   +1 more source

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning

Cell Reports, 2018
Summary: AgRP neurons control peripheral substrate utilization and nutrient partitioning during conditions of energy deficit and nutrient replenishment, although the molecular mechanism is unknown.
Alex Reichenbach, Romana Stark, Mathieu Mequinion, Raphael R.G. Denis, Jeferson F. Goularte, Rachel E. Clarke, Sarah H. Lockie, Moyra B. Lemus, Greg M. Kowalski, Clinton R. Bruce, Cheng Huang, Ralf B. Schittenhelm, Randall L. Mynatt, Brian J. Oldfield, Matthew J. Watt, Serge Luquet, Zane B. Andrews   +16 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Optimizing nitrogen management for young rubber trees: gradients effects on nutrient partitioning and root structural adaptation

Frontiers in Plant Science
IntroductionEfficient nitrogen (N) management is crucial for the sustainable cultivation of rubber tree (Hevea brasiliensis) seedlings.MethodsThis study aimed to determine the effects of low (CK, 32.4 g tree⁻¹), medium (MN, 64.8 g tree⁻¹), and high (HN ...
Yongfa Zhang, Yongfa Zhang, Dongqi Jin, Xuehua Luo, Xuehua Luo, Chunmei Zhao, Chunmei Zhao, Xinxin Xue, Xinxin Xue, Changqi Ren, Changqi Ren, Xiaoshuang Wu, Xiaoshuang Wu, Yu Wang, Yu Wang, Jingmin Zhang, Jingmin Zhang, Wei Luo, Wei Luo, Wenbin Wang, Wenbin Wang   +20 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Partial substitution of nitrogen fertilizer by Chinese milk vetch with different improvement measures achieves a win-win for rice productivity and environmental benefits

Frontiers in Plant Science
IntroductionGreen manuring has been proven to be a sustainable strategy for enhancing paddy soil fertility and reducing chemical fertilizer input. However, the anaerobic decomposition of green manure in flooded soils leads to substantial increase in ...
Shang Han, Shang Han, Rongyan Bu, Guopeng Zhou, Shan Tang, Hui Wang, Min Li, Wenlong Cheng, Ji Wu, Hongjian Gao   +9 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Impact of Phosphorus Fertilization on Leaching, Accumulation, and Microbial Cycling in New Apple Orchards

Agronomy
Field experiments spanning five years were conducted to convert barren mountainous land into apple orchards, testing five phosphorus (P) fertilization schemes: no inorganic P (NP0K), superphosphate (FP), water-soluble inorganic P (WSF), superphosphate ...
Yuwen Shen, Haitao Lin, Rui Xue, Yanan Ma, Yan Song   +4 more
doaj   +1 more source