Results 61 to 70 of about 153,995 (308)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Comparative Proteomic Analysis of Flammulina filiformis Reveals Substrate-Specific Enzymatic Strategies for Lignocellulose Degradation

Horticulturae
Flammulina filiformis, one of the most delicious and commercially important mushrooms, demonstrates remarkable adaptability to diverse agricultural wastes.
Weihang Li, Jiandong Han, Hongyan Xie, Yi Sun, Feng Li, Zhiyuan Gong, Yajie Zou   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Soil disinfestation and optimized nutrient management reduces nitrogen leaching and shapes soil microbial community composition in greenhouse cucumber production systems

Frontiers in Microbiology
High nutrient input leads to problems such as excessive accumulation of soil nutrients, and imbalance of microbial communities. However, there remains significant gaps in the impact of soil disinfestation and optimized nutrient management measures on the
Xilin Guan, Bin Liu, Wenfan Bian, Yufeng Zhang, Xinhao Gao, Xinping Chen, Xinping Chen, Yan Li, Shenzhong Tian   +8 more
doaj   +1 more source

Deriving Land Management Practices for Reduced Nutrient Movement from an Agricultural Watershed Using the AGNPS Model

, 2023
The effect of nutrient management practices and the land-use system on nutrient enrichment in water resources of a hilly watershed was assessed with an event-based agricultural non-point source (AGNPS) model.
Sandrasekaran Manivannan, Om Pal Singh Khola, Venkatachalam Kasthuri Thilagam   +2 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Achieving the goal of the “4‰ initiative” and agricultural sustainability by co-incorporating rice straw and Chinese milk vetch for rice production in southern China

Geoderma
The co-incorporation of rice straw (RS) and Chinese milk vetch (CMV) has been suggested as an optimized agronomic management strategy to improve soil organic carbon (SOC) storage and agricultural sustainability.
Yu Zhang, Wangwang Zhang, Fei Xu, Yuhang Qin, Hao Chen, Yuhong Wu, Shuo Li   +6 more
doaj   +1 more source

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning

Cell Reports, 2018
Summary: AgRP neurons control peripheral substrate utilization and nutrient partitioning during conditions of energy deficit and nutrient replenishment, although the molecular mechanism is unknown.
Alex Reichenbach, Romana Stark, Mathieu Mequinion, Raphael R.G. Denis, Jeferson F. Goularte, Rachel E. Clarke, Sarah H. Lockie, Moyra B. Lemus, Greg M. Kowalski, Clinton R. Bruce, Cheng Huang, Ralf B. Schittenhelm, Randall L. Mynatt, Brian J. Oldfield, Matthew J. Watt, Serge Luquet, Zane B. Andrews   +16 more
doaj   +1 more source

The role of variety as genetic potential in nutrient utilization

, 2015
A container model trial was set up on sandy soil with 5 replications to study the nutrient regime of 16 wine grape varieties in a 10 year program starting in 1982 at Kecskemet-Miklostelep in the Institute for Viticulture and Oenology.
Hajdu, E., André, J.
core   +1 more source

Altering nutrient utilization in animals through transgenesis [PDF]

Nutrition Research Reviews, 1999
AbstractImproved domestic animal productivity is necessary in order to provide for an increasing world population over the next two to three decades and such improvement would be aided by an increase in the efficiency of nutrient utilization. This can be achieved by conventional genetic selection protocols but progress by this approach is slow.
openaire   +2 more sources