Results 71 to 80 of about 153,995 (308)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Optimizing nitrogen management for young rubber trees: gradients effects on nutrient partitioning and root structural adaptation

Frontiers in Plant Science
IntroductionEfficient nitrogen (N) management is crucial for the sustainable cultivation of rubber tree (Hevea brasiliensis) seedlings.MethodsThis study aimed to determine the effects of low (CK, 32.4 g tree⁻¹), medium (MN, 64.8 g tree⁻¹), and high (HN ...
Yongfa Zhang, Yongfa Zhang, Dongqi Jin, Xuehua Luo, Xuehua Luo, Chunmei Zhao, Chunmei Zhao, Xinxin Xue, Xinxin Xue, Changqi Ren, Changqi Ren, Xiaoshuang Wu, Xiaoshuang Wu, Yu Wang, Yu Wang, Jingmin Zhang, Jingmin Zhang, Wei Luo, Wei Luo, Wenbin Wang, Wenbin Wang   +20 more
doaj   +1 more source

Nutrient utilization with and without recycling within farming systems

, 2002
Nutrient balances are used as a measure of nutrient utilization. It is, however, difficult to compare the nutrient utilization between farms, especially if their production systems are different.
Seuri, Pentti
core  

Evolving strategies for single-celled organisms in multi-nutrient environments [PDF]

, 2015
When micro-organisms are in environments with multiple nutrients, they often preferentially utilise one first. A second is only utilised once the first is exhausted. Such a two-phase growth pattern is known as diauxic growth.
David J. Barnes, Barnes, David J., Dominique Chu, Chu, Dominique   +3 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Importance of Cost Offsets for Dairy Farms Meeting a Nutrient Application Standard

The U.S. Environmental Protection Agency requires concentrated animal feeding operations to develop and implement a comprehensive nutrient management plan.
Ribaudo, Marc, Agapoff, Jean
core   +2 more sources

Partial substitution of nitrogen fertilizer by Chinese milk vetch with different improvement measures achieves a win-win for rice productivity and environmental benefits

Frontiers in Plant Science
IntroductionGreen manuring has been proven to be a sustainable strategy for enhancing paddy soil fertility and reducing chemical fertilizer input. However, the anaerobic decomposition of green manure in flooded soils leads to substantial increase in ...
Shang Han, Shang Han, Rongyan Bu, Guopeng Zhou, Shan Tang, Hui Wang, Min Li, Wenlong Cheng, Ji Wu, Hongjian Gao   +9 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Impact of Phosphorus Fertilization on Leaching, Accumulation, and Microbial Cycling in New Apple Orchards

Agronomy
Field experiments spanning five years were conducted to convert barren mountainous land into apple orchards, testing five phosphorus (P) fertilization schemes: no inorganic P (NP0K), superphosphate (FP), water-soluble inorganic P (WSF), superphosphate ...
Yuwen Shen, Haitao Lin, Rui Xue, Yanan Ma, Yan Song   +4 more
doaj   +1 more source