Results 71 to 80 of about 140,189 (262)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Microbial-mediated structural changes in humic acid increase phosphorus availability in the fertosphere

Geoderma
It is widely accepted that humic acid-enhanced phosphate fertilizers (HAEP) improve crop yield and phosphorus (P) use efficiency, largely because the carboxyl-rich structure of humic acid (HA) reduces P fixation and enhances soil P availability. However,
Yanna Luo, Yunbo Niu, Wentao Pan, Lei Shi, Yingqiang Zhang, Xinxin Ye, Qizhong Xiong, Bingqiang Zhao, Jianyuan Jing   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Controlled-Release Nitrogen Fertilizer Enhances Saline–Alkali Soil Organic Carbon by Activating Straw Decomposition Agents

Agronomy
Soil organic carbon (SOC) represents a crucial factor in agricultural production, and its accumulation is influenced by soil microbial community and microbial metabolism.
Rui Xue, Zhengrui Wang, Qing Liu, Kun Song, Shanda Yuan, Mei Wang, Yuwen Shen, Guangqing Ji, Haitao Lin   +8 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Prediction of Soil Total Nitrogen Through Vis–NIR Spectroscopy and Machine Learning: From Model Comparison to Explainability

Soil Systems
Rapid and cost-effective estimation of soil total nitrogen (TN) is essential for soil fertility assessment and nutrient management. However, the performance of laboratory visible–near-infrared (Vis–NIR) models is shaped not only by preprocessing and ...
Shengchang Huai, Qingyue Zhang, Yuwen Jin, Shenzhong Tian, Yueming Chen, Xilin Guan, Tao Sun, Shenqiang Lv, Zichao Zhao, Weijia Yu, Ran Li, Gilles Colinet, Changai Lu, Xinhao Gao   +13 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Lead remediation by geological fluorapatite combined with Penicillium Oxalicum and Red yeast

Microbial Cell Factories
Phosphate solubilizing fungi Penicillium oxalicum (POX) and Red yeast Rhodotorula mucilaginosa (Rho) have been applied in Pb remediation with the combination of fluorapatite (FAp), respectively.
Qiang Guan, Xiaohui Cheng, Yue He, Yifan Yan, Lei Zhang, Zhan Wang, Liangliang Zhang, Da Tian   +7 more
doaj   +1 more source

Effect of lateral flushing on emitter clogging in drip irrigation using high-sediment water

Agricultural Water Management
High sediment content in irrigation water is a common challenge in agricultural regions, leading to increased clogging of emitters and reduced system efficiency. Lateral flushing (LF) is an effective measure to reduce emitter clogging for drip irrigation
Changjian Ma, Cuiling Jiang, Yan Li, Ning Shi, Shenglin Liu, Xinhui Hu, Zhaohui Liu, Zeqiang Sun, Tahir Muhammad   +8 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source