Results 91 to 100 of about 140,189 (262)

Effect of combined nitrogen and phosphorus fertilization on summer maize yield and soil fertility in coastal saline-alkali land

Agricultural Water Management
Soil salinization limits food production and land use efficiency. Proper nitrogen and phosphate fertilizer application can improve saline soils, but the optimal ratio under saline-alkali conditions is unclear.
Changjian Ma, Wu Wenbiao, Peng Hou, Yue Wang, Bowen Li, Huabin Yuan, Lining Liu, Xuejun Wang, Zeqiang Sun, Yan Li   +9 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Priority effects outweigh nitrogen deposition in shaping C3–C4 grass competition in desert steppe ecosystems

Global Ecology and Conservation
Nitrogen (N) deposition and altered sowing patterns are key drivers of grassland community dynamics, influencing species interactions, resource allocation, and ecosystem functioning.
Kun Zhao, Fen Wang, Qian Liu, Haina Hu, Shenyi Jiang, Hui Gao, Chunxue Han, Mengli Zhao, Guodong Han, Haigang Li   +9 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Combined Application of Chemical and Organic Fertilizers: Effects on Yield and Soil Nutrients in Spring Wheat under Drip Irrigation

Agronomy
In this study, we established a feasible fertilization programming method for wheat production by exploring the effects of the combined application of chemical and organic fertilizers on wheat yield, nutrient uptake, soil nutrient content, and fertilizer
Xiangjie Chang, Hao He, Liyang Cheng, Xiaojuan Yang, Shuai Li, Mengmeng Yu, Jifeng Zhang, Junhua Li   +7 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Lake carbon loss driven by changed microbial carbon utilization through increased anthropogenic land-use intensity

Communications Earth & Environment
The conversion of intrinsic lands to anthropogenic uses has increased nutrient inputs for lake microbes, profoundly influencing biogeochemical processes, particularly carbon cycling.
Yao Guo, Shuzhen Li, Songsong Gu, Zhongyi Hua, Jinhui Pang, Bingqian Xu, Kaixuan Wu, Disong Chen, Dongru Qiu, Yanxin Wang, Zhenbin Wu, Qiaohong Zhou   +11 more
doaj   +1 more source