Results 131 to 140 of about 798,130 (316)

Discovery of Jaspamycin from marine-derived natural product based on MTA3 to inhibit hepatocellular carcinoma progression

Scientific Reports
Studies have underscored the pivotal role of metastasis-associated protein 3 (MTA3) as a cancer regulator, yet its potential as a drug target across cancers necessitates comprehensive evaluation.
Yihan Liu, Tong Lu, Runze Li, Rui Xu, Denis Baranenko, Lida Yang, Dan Xiao   +6 more
doaj   +1 more source

Ultrasound-assisted extraction of polysaccharide from Allium chinense G. Don epidermal waste: Evaluation of extraction mechanism, physicochemical properties, and bioactivities

Ultrasonics Sonochemistry
Allium chinense G. Don waste (ACGD) has an abundance of polysaccharides (ACGDP). Therefore, in this study, a method for extraction of ACGDP from ACGD by ultrasonic-assisted hot water extraction (UAE) based on ultrasonic cleaning equipment was developed ...
Jiangfei Li, Guanjun Ye, Zhilong Zhou, Jianlong Wang, Jiayu Wang, Ting Ju, Alejandro Cifuentes, Elena Ibañez, Denis Baranenko, Haitian Zhao, Weihong Lu   +10 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Microorganisms Cycling Soil Nutrients

, 2019
Microorganisms drive nutrient cycles in soil, and without this key activity, many essential elements would not be available to plants. Conversely, without the input of carbon and energy, primarily from photosynthesis by green plants, soil would consist ...
Hirsch, P. R.
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Porous starch as an effective carrier for sustained release and bioactivity protection of cannabidiol full spectrum oil

Current Research in Food Science
Full-spectrum cannabidiol oil (CFSO) has attracted growing attention across industries for its multiple health benefits, but its poor water solubility and low bioavailability remain unresolved challenges.
Jiangfei Li, Naicheng Xin, Guanjun Ye, Zhilong Zhou, Junwen Wang, Ting Ju, Heqi Gao, Yang Gao, Xianghui Meng, Alejandro Cifuentes, Weihong Lu, Yingchun Zhang   +11 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Chemical and biological processes for nutrients removal and recovery

, 2016
This chapter gives an overview on the main technologies for nutrient removal from industrial wastewater by focusing on principles and operational parameters of real applications.
N. Tayà, Pedemonte D. C., C. Ponsa, S. Fatone, Frison   +4 more
core   +1 more source

Nitrogen Use Efficiency in Maize over Sixteen Years of Unbalanced Fertilization with Nitrogen and Potassium

Agriculture
Adequate fertilization with nitrogen (N) and potassium (K) is essential to sustain crop productivity and minimize nitrogen losses to the environment. However, the increasing imbalance in fertilizer use in Poland, with low potassium inputs, may impair ...
Agnieszka Rutkowska, Beata Suszek-Łopatka   +1 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source