Results 201 to 210 of about 2,469,745 (360)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Glutamate as a therapeutic strategy to promote liver regeneration

Clinical and Translational Medicine
María del Mar Rigual, Nabil Djouder
doaj   +1 more source

Foods, Nutrients, and Dietary Patterns: Interconnections and Implications for Dietary Guidelines.

Advances in Nutrition, 2016
L. Tapsell, E. Neale, A. Satija, F. Hu
semanticscholar   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Preferences for post‐traumatic osteoarthritis prevention strategies in individuals with anterior cruciate ligament injury

Arthritis Care &Research, Accepted Article.
Objectives There is growing interest in evaluating new strategies to delay or prevent post‐traumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury.
Kevin Kennedy, Lily Waddell, Adam Easterbrook, Jeffrey N. Katz, Cale Jacobs, Morgan Jones, Faith Selzer, Elena Losina, Liana Fraenkel, Nick Bansback   +9 more
wiley   +1 more source

Oxidation and allocation of nectar amino acids during butterfly flight. [PDF]

J Exp Biol
Tigreros N, Davidowitz G, Burkholder C, Chabaud C.   +3 more
europepmc   +1 more source

Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps.

American Journal of Clinical Nutrition, 2017
T. K. Thorning, H. C. Bertram, J. Bonjour, L. D. de Groot, D. Dupont, E. Feeney, R. Ipsen, J. Lecerf, A. Mackie, M. McKinley, M. Michalski, D. Rémond, U. Risérus, S. Soedamah-Muthu, T. Tholstrup, C. Weaver, A. Astrup, I. Givens   +17 more
semanticscholar   +1 more source

Clinical Outcomes of Patients Within the Rheumatoid Arthritis Care Pathway Cohort at a Tertiary Care Integrated Delivery Network: A Comparison to Usual Care

Arthritis Care &Research, EarlyView.
Objective We aimed to compare clinical outcomes between patients in the Allegheny Health Network rheumatoid arthritis (RA) care pathway and patients receiving usual care. Methods The care pathway initiative implements guideline‐based best practice alongside multidisciplinary team‐based care.
Tarun Sharma, Tyson S. Barrett, Teigan Dwyer, Nancy Campbell, Jessica Heintzinger, Ellen Kraemer, Adam Dore, Susan Manzi   +7 more
wiley   +1 more source

Global marine fish trade networks track international pathways of nutrients and contaminants. [PDF]

Eco Environ Health
Zhu Y, Ho QT, Robinson JPW, Kjellevold M, Chang R, Fuglebakk E, Ma J, Song S, Dahl L, Nøstbakken OJ, Markhus MW, Nilsen BM, Kögel T, Lundebye AK, Azad AM, Uzomah A, Kolding J, Lien VS, Wiech M, Zhang Y, Maage A, Frøyland L, Bank MS.   +22 more
europepmc   +1 more source