Results 241 to 250 of about 10,963,897 (387)

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Associations Between Nutritional Factors, Obesity and Ocular Diseases: A Narrative Literature Review. [PDF]

Nutrients
Bogdănici CG, Bogdănici CM, Pavel IA, Ganea CV, Donica VC, Cărăușu EM.   +5 more
europepmc   +1 more source

An Engineered Solidified Peptide Hemocyte Sponge as Nanomotor Storage to Combat Bacterial Colitis

Advanced Science, EarlyView.
Peptides immobilized via nickel coordination can stabilize the framework structure. Following coating with red blood cell membranes, these constructs are capable of continuously sequestering endotoxins and mitigating colonic pathogenic damage by alleviating bacterial‐induced ferroptosis.
Yuxin Fang, Jianming Yan, Tongxin Yu, Zichuan An, Kaikai Lv, Chenyu Xue, Hongyang Yu, Na Dong, Anshan Shan   +8 more
wiley   +1 more source

CONUT score as a prognostic biomarker in progressive pulmonary fibrosis: a simple tool for clinical risk stratification. [PDF]

BMC Pulm Med
Akkurt ES, Sahin Ozdemirel T, Akıncı Ozyurek B, Ensarioglu K, Duvenci Birben O, Zenbilli E.   +5 more
europepmc   +1 more source

The effect of regular hemodialysis on the nutritional status of children with end-stage renal disease

, 2015
EmadE Ghobrial, S. H. Abed, HalaM Lotfy, SamarM Sabry   +3 more
openalex   +1 more source

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source

Crippling konzo in DRC, three generations later [PDF]

, 2014
Banea Mayambu, Jean-Pierre, Diasolua Ngudi, Delphin, Lambein, Fernand   +2 more
core   +1 more source

Association between controlling nutritional status score and mortality in older patients with dysphagia in Japan: <b>a</b> retrospective cohort study. [PDF]

Front Nutr
Wang Y, Sun C, Tian X, Fan F.
europepmc   +1 more source

Nutritional problems in older adults with Alzheimer’s disease: Risk of malnutrition and sarcopenia

, 2021
Danielle Rodrigues Lecheta, Maria Eliana Madalozzo Schieferdecker, Ana Paula de Queiroz Mello, Ivete Berkenbrock, João Cardoso Neto, Eliane Mara Cesário Pereira Maluf   +5 more
openalex   +1 more source

12‐HETE Is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture

Advanced Science, EarlyView.
In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Yuyu Li, Jiaqi Yu, Weiyao Chen, Xue Wang, Xin Tan, Jing Cui, Yihao Wang, Xuan Xu, Rui Lin, Zhengkai Wang, Wenxi Jiang, Yongliang Zhong, Jie Du, Yuan Wang   +13 more
wiley   +1 more source