Results 211 to 220 of about 9,018,644 (408)

From Natural Discovery to AI‐Guided Design: A Curated Collection of Compact Enhancers for Crop Engineering

open access: yesAdvanced Science, EarlyView.
ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao   +14 more
wiley   +1 more source

Gabpα‐Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat

open access: yesAdvanced Science, EarlyView.
This study identifies the Gabpα–Pparγ complex as a key transcriptional regulator that couples glycolysis to lactate‐driven thermogenesis in brown adipose tissue by directly activating Eno1 transcription. ‌Competitive disruption of this interaction impairs lactate metabolism and thermogenic capacity.
Zhihan Wang   +22 more
wiley   +1 more source

Construction of a nutritional risk prediction model for ovarian cancer patients based on Logistic regression and decision tree

open access: yesHuli yanjiu
ObjectiveTo construct a nutritional risk prediction model for ovarian cancer patients based on logistic regression and classification and regression tree(CART).MethodsA total of 326 ovarian cancer patients admitted to the oncology department of a ...
WANG Jing   +5 more
doaj  

The role of nutritional risk indexes in predicting physical frailty and its progression in community-dwelling older adults. [PDF]

open access: yesJ Nutr Health Aging
Hsu Y   +8 more
europepmc   +1 more source

The Gut Commensal Butyricimonas Virosa Modulates Gut Microbiota‐Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease

open access: yesAdvanced Science, EarlyView.
This study reveals that dietary stachyose enriches Butyricimonas virosa, effectively attenuating metabolic dysfunction‐associated steatotic liver disease (MASLD). Mechanistically, B. virosa enhances gut thiamine monophosphate synthesis, which elevates hepatic thiamine pyrophosphate levels.
Ningning He   +17 more
wiley   +1 more source

Comparison of application value of mNUTRIC and NRS⁃2002 in prognosis evaluation of critically ill patients

open access: yesHuli yanjiu
ObjectiveTo evaluate the nutritional risk of patients in emergency intensive care unit (EICU) using mNUTRIC score and NRS-2002, and to compare the value of the two tools in assessing 28-day mortalityMethodsPatients admitted to the EICU from February to ...
WANG Lingli   +5 more
doaj  

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