Results 191 to 200 of about 25,009 (258)

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Practices, barriers, and opportunities for dietitians-nutrionists in critical care in Latin America: A cross-sectional study. [PDF]

JPEN J Parenter Enteral Nutr
Crovetto M, Parra-Soto S, Durán-Aguero S, Cordón-Arrivillaga K, Canicoba M, Landaeta-Díaz L, Bejarano JJ, Mauricio S, Nava-González EJ, Carpio-Arias V, Cerezo S, Ivankovich S, Ortiz A, Nuñez-Martinez B, Meza-Miranda ER, de Baptista GMA, Morales M, Miranda-Durán M, Carrera-Gil F.   +18 more
europepmc   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Delivering virtual cardiac rehabilitation within correctional facilities to fulfill the decree of Estelle versus Gamble. [PDF]

NPJ Digit Med
Matsumura ME, Nelson F, Zimmerman A, Bower-Stout CL, Matsumura TS, Martin B.   +5 more
europepmc   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Uncommon presentation of hypoglycemic coma in a pregnant patient with anorexia nervosa: a case report. [PDF]

Ann Med Surg (Lond)
Omarion Z, Jayouse B, Khalil OR.
europepmc   +1 more source

Formative Development and Acceptability of a Lifestyle Weight Management Intervention for Breast Cancer Survivors in Greece: The NutriLife Study. [PDF]

Healthcare (Basel)
Perperidi M, Skeparnakou E, Strongylou D, Leptopoulou A, Tsiampalis T, Tsapakidis K, Saloustros E, Theodorakis Y, Androutsos O.   +8 more
europepmc   +1 more source

Real-world outcomes of managing autosomal-dominant polycystic kidney disease using a medical food as part of a nutrition and lifestyle program to improve renal and metabolic health. [PDF]

Front Nutr
Muensterman E, Torres JA, Weimbs T.
europepmc   +1 more source

Multidisciplinary Collaborative Nursing Management Improves Health Behaviors and Psychological Status in Patients with Diabetes Mellitus and Coronary Heart Disease. [PDF]

J Multidiscip Healthc
Liu Q, Li Z.
europepmc   +1 more source