Results 211 to 220 of about 35,092 (241)

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Child with genetically confirmed Prader-Willi syndrome. [PDF]

BMJ Case Rep
Kahssay MG, Oyieke K, Hoybye C.
europepmc   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

A Conceptual Framework for Managing Oral Intake in Head and Neck Cancer Patients Undergoing Chemoradiotherapy. [PDF]

Nutrients
Cintoni M, Leonardi E, Raoul PC, Longo S, Massaccesi M, Palombaro M, Egidi G, Pastore F, Rinninella E, Capristo E, Gasbarrini A, Gambacorta MA, Mele MC.   +12 more
europepmc   +1 more source

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

The NUTRI-OBEDIGITHUM Pathway: Integrating Personalized Exchange-Based Nutrition into Digitally Enabled Obesity Care and a Retrospective Real-World Cohort Analysis. [PDF]

Nutrients
Vázquez C, Cárdenas-Salas J, Arrieta F, Sánchez A, Alcarria M, Melchor A, Luca B, Yela C, Fernández Y, Prieto A, Paniagua A, Ortega M, García-Valdecasas L, Burrero A, Martínez A, Aguirre N, Aganzo M, de Cos AI, Martín E, Gómez-Borrallo J, Piñera M, Sierra R, Del Olmo M, Mas-Fontao S, Montoya T.   +24 more
europepmc   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Decoding of Nocturnal Fasting and Health: Possible Role of Zeitgebers and Melatonin. [PDF]

Ann Neurosci
Aggarwal N, Magan D, Sharma TK, Yadav RK.   +3 more
europepmc   +1 more source

Tuberculosis- learning about experience with nutritional supplementation (TB LENS): Perspectives on a nutritional supplementation for persons with TB and their household contacts. [PDF]

Glob Public Health
Carwile M, Jain K, Dauphinais M, Cintron C, Janarthanan, Locks LM, Maloomian K, Prakash Babu S, Rajkumari N, R M, Narasimhan PB, Sabin L, Sinha P, Lakshminarayanan S.   +13 more
europepmc   +1 more source

Perceptions of Registered Dietitian Nutritionists (RDNs) on the Use of Artificial Intelligence (AI) in Clinical Nutrition Care: A Cross-Sectional Survey Within a Large U.S. Healthcare System. [PDF]

Nutrients
Johnson D, Hurt RT, Mundi MS, Salonen BR, Bonnes SL, Schroeder DR, Fokken SC, Croghan IT, Edakkanambeth Varayil J.   +8 more
europepmc   +1 more source