Results 151 to 160 of about 16,307,918 (298)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Structural Basis of Lipopolysaccharide O-Antigen Chain Length Modality. [PDF]

Research (Wash D C)
Wiseman B, Widmalm G, Högbom M.
europepmc   +1 more source

Structure and biology of Shigella flexneri O antigens [PDF]

Journal of Medical Microbiology, 1987
D A, Simmons, E, Romanowska
openaire   +2 more sources

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

wbp-encoded LPS O-antigen architecture as a prognostic and therapeutic target in Pseudomonas aeruginosa keratitis. [PDF]

EBioMedicine
Wei M, Zhang Z, Zhao X, Xu B, Shi Q, Cheng Z, Xu X, Wei Z, Lu X, Li L, Liang Q.   +10 more
europepmc   +1 more source

Ultrafast visual detection of Streptococcus suis via HtpsC‐targeted LAMP–CRISPR–Cas12a coupled with lateral flow immunochromatography

FEBS Open Bio, EarlyView.
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li, Miao Xin, Xiao‐wen Cui, Shi‐yin Yu, Fei Meng, Min Cao, Xiao‐hui Xiong, Yi‐chen Lu   +7 more
wiley   +1 more source

A single nucleotide polymorphism collapses phase variation and drives short-sighted evolution of O-antigen in <i>Salmonella</i>. [PDF]

Gut Microbes
Cheng Y, Zhang W, Nickerson R, Lu Q, Guo Y, Hu Q, Zhang R, Wen G, Huang Q, Zhou R, Shao H, Cheng Z, Luo Q, Zhang T.   +13 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Enteric populations of <i>Escherichia coli</i> are likely to be resistant to phages due to O antigen expression. [PDF]

mSphere
Berryhill BA, Gil-Gil T, Burke KB, Fontaine J, Brink CE, Harvill MG, Goldberg DA, Navas JN, May KL, Grabowicz M, Konstantinidis KT, Levin BR, Woodworth MH.   +12 more
europepmc   +1 more source