Results 101 to 110 of about 15,530,041 (302)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Seronegative spondyloarthropathies and HLA antigens in a Mestizo population

, 1984
HLA-A and -B antigens incidence were investigated in 100 cases of Seronegative Spondyloarthropathies and in 303 control individuals of a Venezuelan Mestizo population.
Bianco Colmenares, Nicolás E., Abadí, Isaac, Pérez R., Gloria E., Paul M., Hernándo   +3 more
core  

Cross-protection provided by live Shigella mutants lacking major antigens

, 2013
The immune response elicited by Shigella infections is dominated by serotype-specific antibodies recognizing the LPS O-antigens. Although a marked antibody response to invasion plasmid antigens (Ipa-s) shared by all virulent strains is also induced ...
Szijartó, Valéria, Hunyadi-Gulyás, Éva, Nagy, Gábor, Emődy, Levente, Pál, Tibor   +4 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen:Implications for parasite strain-specific immunity [PDF]

, 2009
Although immunodominance of CD8(+) T-cell responses is a well-recognised feature of viral infections, its role in responses to more antigenically complex pathogens is less clear.
Connelley, T., Burrells, A, W. Ivan Morrison, Declan J. McKeever, Connelley, Timothy, Taracha, Evans L., Connelly, T, McKeever, DJ, Morrison, WI, Simon P. Graham, Burrells, A., MacHugh, ND, McKeever, D J, Taracha, E.L.N., Niall D. MacHugh, Roger Pelle, Ellis, SA, McKeever, Declan J., MacHugh, N D, Connelley, T, Evans L. Taracha, Ellis, S A, Graham, SP, Pelle, Roger, Ellis, Shirley A., MacHugh, Niall D., Formisano, Principia, Formisano, P, Principia Formisano, Taracha, EL, Ellis, S.A., Shirley A. Ellis, Taracha, E L, Alison Burrells, Pelle, R, Graham, Simon P., Graham, S P, Timothy Connelley, Formisano, P., Morrison, W. Ivan, Burrells, Alison, Graham, S.P.   +41 more
core   +1 more source

Unique or not unique? Comparative genetic analysis of bacterial O-antigens from the Oxalobacteraceae family.Supplementary_data

, 2022
This is Supplementary files for the paper "Unique or not unique? Comparative genetic analysis of bacterial O-antigens from the Oxalobacteraceae family".
Afonnikova Svetlana, Komissarov Aleksey, Kuchur Polina   +2 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Non-precipitating protein antigens

, 1941
When some protein antigens are heated with serologically unspecific proteins they cease to be precipitated by their antisera, and their behaviour in vitro approximates to that of non–precipitating haptens.
Bawden, F. C., Kleczkowski, A., Bawden, Frederick Charles, Kleczkowski, Alfred Alexander Peter   +3 more
core   +1 more source

Farmer’s Lung Disease: the Development of Antigens in Moulding Hay [PDF]

, 1964
Antigens important in farmer’s lung disease (FLH antigen complex) developed in wet hay ( 2 30 yo water content) 4-6 days after baling; their development was associated with increases in pH value of the hay, in content of soluble and volatile nitrogen ...
P. H. Gregory, Maureen E. Lacey, Rothamsted Experimental Station, F. A. Skinner, G. N. Festenstein, Festenstein, G. N., Lacey, M. E., Skinner, F. A., Gregory, P. H., Jenkins, P. A., P. A. Jenkins, Pepys, J., J. Pepys   +12 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source