Results 91 to 100 of about 15,530,041 (302)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

The development of immunoassays for the detection of bovine brucellosis and aflatoxin B1 [PDF]

, 2004
The research discussed in this thesis focuses on the development and characterisation of immunoassays for the detection of aflatoxin Bi (AFBi), a toxic fungal metabolite, and for the diagnosis of bovine brucellosis, a highly contagious disease of cattle ...
Dunne, Lynsey
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Method for stably binding antigens and allergens to solid supports and supports obtained

, 1991
A method for stably binding antigens and allergens to a polystyrene supports, which consists in reacting a polyfunctional aldehyde with the polystyrene solid phase; in washing said solid phase to remove the excess aldehyde; in incubating the so processed
O. Brenna, P. Falagiani
core   +1 more source

Polysaccharide-conjugate vaccines for Burkholderia pseudomallei based on the O-antigens of serotypes A and B

Carbohydrate Polymer Technologies and Applications
Burkholderia pseudomallei, a facultative intracellular pathogen, has been classified into three distinct serotypes: A, B, and B2. Serotype A is the most prevalent, serotype B is the next most common. However, no vaccines target B.
Jingmin Yan, Jinzhu Huang, Xiaoxue Lu, Xiaoyi He, Chenglong Rao, Dongqi Nan, Haiyang Lu, Linming Guo, Qian Li, Shiwei Wang, Xuhu Mao, Xiancai Rao   +11 more
doaj   +1 more source

Reações locais e níveis de antitoxina circulante decorrentes de administração do toxóide tetânico: estudo comparativo entre Ped-o-Jet e seringa hipodérmica Local reactions and antitoxin levels induced by the administration of tetanus toxoid: a comparative study between Ped-o-Jet and hypodermic syringe

Revista de Saúde Pública, 1985
Com o objetivo de comparar reações locais e conversão sorológica apresentadas por adultos que receberam o toxóide tetânico através de Ped-o-Jet (via subcutânea) ou de seringa hipodérmica (via intramuscular), o toxóide foi administrado a 472 recrutas do ...
Ana Maria Aratangy Pluciennik, Edda de Rizzo, Hisako Gondo Higashi, Clarice Kazue Konishi, Edna Santos Freitas, Pedro Veneziani, Yiu Takabayashi, Elianne Egma Esteves da Silveira   +7 more
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Serodiagnosis of Echinococcus spp. infection: explorative selection of diagnostic antigens by peptide microarray [PDF]

, 2010
BACKGROUND: Production of native antigens for serodiagnosis of helminthic infections is laborious and hampered by batch-to-batch variation. For serodiagnosis of echinococcosis, especially cystic disease, most screening tests rely on crude or purified ...
Maag, Eva, List, C, List, C., Gottstein, Bruno, Gottstein Bruno, Felger Ingrid, Felger, Ingrid, Qi, W, Gottstein, B., Ingrid Felger, Maag Eva, Qi Weihong, Müller, N., Felger, I, Müller, Norbert, Norbert Müller, List, Claudia, Gottstein, B, Müller Norbert, Felger, I., Maag, E., Müller, N, Qi, W., Eva Maag, Bruno Gottstein, List Claudia, Claudia List, Maag, E, Qi, Weihong, Weihong Qi, Qi W, List C, Gottstein B, Maag E, Müller N, Felger I   +35 more
core   +2 more sources

Modification of H-2 Antigenic Sites by Enzymatic Treatment Influences Virus-Specific Target Cell Lysis [PDF]

, 1976
Vaccinia virus-infected cells were treated enzymatically to remove H-2 antigenic sites. The effect of this procedure on virus-specific cell-mediated cytolysis (CMC) and virus-specific antibody-mediated cytolysis (AMC) was tested. Due to the inhibition of
Koszinowski, Ulrich H., Ertl, H.
core   +1 more source