Results 71 to 80 of about 15,530,041 (302)

Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a, based on late stage mono-O-acetylation and/or site-selective oxidation

, 2013
International audienceShigella flexneri serotypes 6 and 6a are closely related bacteria causing shigellosis in humans. Their O-antigens are {→4)-β-d-GalpA-(1→3)-β-d-GalpNAc-(1→2)-[3Ac/4Ac]-α-l-Rhap-(1→2)-α-l-Rhap-(1→}n acidic polysaccharides ({ABAcCD}n),
Mulard, Laurence,, Mulard, Laurence, A, Chassagne, Pierre, Raibaut, Laurent, Guerreiro, Catherine   +4 more
core   +1 more source

Proteomic Selection of Immunodiagnostic Antigens for Trypanosoma congolense [PDF]

, 2014
Animal African Trypanosomosis (AAT) presents a severe problem for agricultural development in sub-Saharan Africa. It is caused by several trypanosome species and current means of diagnosis are expensive and impractical for field use.
Napier, Grant B., Grant B Napier, Napier Grant B., Lauren Sullivan (384455), Crozier, Thomas W. M., Sullivan Lauren, Jennifer R Fleming, Sullivan, Lauren, Michael A J Ferguson, Sastry, Lalitha, Lalitha Sastry (577009), Fleming Jennifer R., Ferguson Michael A. J., Jennifer R. Fleming, Sastry Lalitha, Michael A. J. Ferguson (166662), Lalitha Sastry, Thomas W M Crozier, Grant B. Napier (477160), Grant B. Napier, Ferguson, Michael A. J.; id_orcid, Lauren Sullivan, Thomas W. M. Crozier, Jennifer R. Fleming (577008), Michael A. J. Ferguson, Crozier Thomas W. M., Thomas W. M. Crozier (577010), Ferguson, Michael A. J., Fleming, Jennifer R.   +28 more
core   +1 more source

Dual-Antigen Subunit Vaccine Nanoparticles for Scrub Typhus

Pathogens, 2023
Orientia tsutsugamushi is the causative pathogen of scrub typhus, an acute febrile disease prevalent in the Asia–Pacific region that is spread to people through chigger bites. Despite the emerging threat, there is no currently available vaccine against O.
Jaeyoung Park, Zhiwen Zhang, Tatyana Belinskaya, Alexandra N. Tsoras, Chien-Chung Chao, Le Jiang, Julie A. Champion   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Characterization of vaccine antigens of meningococcal serogroup W isolates from Ghana and Burkina Faso from 2003 to 2009 [PDF]

, 2014
Neisseria meningitidis is a major cause of bacterial meningitis and a considerable health problem in the 25 countries of the 'African Meningitis Belt' that extends from Senegal in West Africa to Ethiopia in the East.
Calman MacLennan, Gerd Pluschke, Koeberling, Oliver, Oliver Koeberling, Ispasanie, Emma, MacLennan, Calman, Emma Ispasanie, Ali Sie, Abraham Hodgson, Pluschke, Gerd, Hodgson, Abraham, Sie, Ali, Pluschke G, MacLennan C, Ispasanie E, Sie A, Hodgson A, Koeberling O   +17 more
core   +1 more source

Enterobacterial Common Antigen: Synthesis and Function of an Enigmatic Molecule

mBio, 2020
The outer membrane (OM) of Gram-negative bacteria poses a barrier to antibiotic entry due to its high impermeability. Thus, there is an urgent need to study the function and biogenesis of the OM.
Ashutosh K. Rai, Angela M. Mitchell
doaj   +1 more source

Structure and genetics ofShigellaO antigens [PDF]

FEMS Microbiology Reviews, 2008
This review covers the O antigens of the 46 serotypes of Shigella, but those of most Shigella flexneri are variants of one basic structure, leaving 34 Shigella distinct O antigens to review, together with their gene clusters. Several of the structures and gene clusters are reported for the first time and this is the first such group for which ...
Bin, Liu, Yuriy A, Knirel, Lu, Feng, Andrei V, Perepelov, Sof'ya N, Senchenkova, Quan, Wang, Peter R, Reeves, Lei, Wang   +7 more
openaire   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

CLASSIFICATION OF PSEUDOMONAS AERUGINOSA O ANTIGENS BY IMMUNOELECTROPHORESIS [PDF]

Journal of Medical Microbiology, 1975
Heated saline extracts of 89 strains, and (1) supernates of phenol-water extracts (L1 fractions), (2) purified lipopolysaccharide, (3) trichloracetic-acid (TCA) extracts, and (4) sodium-hydroxide extracts of 23 strains representing all Pseudomonas aeruginosa O antigens were subjected electrophoresis.
B, Lányi, M M, Adám, A, Szentmihályi
openaire   +2 more sources