Results 161 to 170 of about 123,332 (275)

Model‐Informed Approaches for Pediatric Type 2 Diabetes Evidence Generation: Insights from a Model‐Based Longitudinal HbA1c Meta‐Analysis from EMA Marketing Authorization Applications

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Evidence generation for antihyperglycemic therapies in pediatric type 2 diabetes mellitus (T2DM) remains challenging, with most randomized trials failing to demonstrate statistically significant reductions in glycated hemoglobin (HbA1c), partly due to substantial between‐subject variability.
Pieter J. Colin   +2 more
wiley   +1 more source

Exponentially‐constrained Gaussian mixture model for quantifying vertical development of water‐conducting fracture zones in lithologically stratified mining roofs

open access: yesDeep Underground Science and Engineering, EarlyView.
This study proposes an exponentially‐constrained Gaussian mixture model (EcGMM) to quantify vertical fracture heterogeneity in stratified roof strata. The model integrates a piecewise exponential decay term capturing global stress dissipation with Gaussian components representing localized fracture intensification at lithological interfaces.
Huiqing Yuan   +5 more
wiley   +1 more source

Closed‐form stress solution and minimum safe burial depth correction for shallow‐buried large‐diameter energy storage chambers

open access: yesDeep Underground Science and Engineering, EarlyView.
This study develops a closed‐form solution for stress analysis of shallow‐buried large‐diameter compressed air energy storage (CAES) chambers, explicitly incorporating free surface, lateral pressure, and gravity gradient effects. Validated against numerical simulations, the solution accurately captures stress redistribution and reveals upward migration
Zeyuan Sun, Cheng Zhao, Jinquan Xing
wiley   +1 more source

Nanoscale Mapping of Transition Metal Ordering in Individual LiNi<sub>0.5</sub>Mn<sub>1.5</sub>O<sub>4</sub> Particles Using 4D-STEM. [PDF]

open access: yesSmall Methods
Oney G   +10 more
europepmc   +1 more source

Orthodentine‐osteodentine and osteocytic‐anosteocytic transition inferred from Silurian stem chondrichthyan dermal jawbones with ever‐white teeth overgrown by brown denticles

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background The dentigerous jawbones of a 423‐million‐year‐old stem chondrichthyan (ischnacanthid acanthodian) carry a characteristic combination of multi‐row non‐shedding white teeth with brownish overgrowing denticles. The color distinction makes it a good model for observing the interaction between two odontode lineages, but the nature of ...
Jia‐Cih Kang   +3 more
wiley   +1 more source

Engineering the Lattice and Electronic Configurations of N‐Rich‐CoMoCN by Mo Doping and N Enrichment for Enhanced Water Splitting

open access: yesEcoEnergy, EarlyView.
This study design Mo‐doped and N‐rich‐CoMoCN bimetal for bi‐functionally efficient overall water splitting catalysts by constructing an active site and engineering the interfacial Co6Mo6C2/Co heterojunction in a N‐doped porous carbon matrix and study on the performance of catalyst for electrocatalytic.
Huimin Yang   +12 more
wiley   +1 more source

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