Results 121 to 130 of about 214,059 (308)

Plasmodium falciparum merozoite surface protein 3 is a target of allele-specific immunity and alleles are maintained by natural selection [PDF]

, 2006
BACKGROUND: Plasmodium falciparum merozoite surface protein (MSP) 3 is an asexual blood-stage malaria vaccine candidate antigen. Sequence polymorphisms divide alleles into 2 major types, but the adaptive and immunological significance of the types has ...
Greenwood, Brian M, Conway, David J, Lloyd, JM, Greenwood, BM, Tetteh, Kevin KA, Conway, DJ, Lloyd, Jennie M, Polley, SD, Bojang, KA, Akpogheneta, Onome J, Tetteh, KK, Bojang, Kalifa A, Polley, Spencer D, Akpogheneta, OJ   +13 more
core   +1 more source

Preference of Bacterial Rhamnosyltransferases for 6-Deoxysugars Reveals a Strategy To Deplete O-Antigens. [PDF]

J Am Chem Soc, 2023
Harnagel AP, Sheshova M, Zheng M, Zheng M, Skorupinska-Tudek K, Swiezewska E, Lupoli TJ.   +6 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Immunogenicity evaluation of altSonflex1-2–3 Shigella vaccine across mice, rats, and rabbits to inform human translational insights

Frontiers in Immunology
Shigella, a leading cause of bacillary dysentery, represents a significant global health challenge, particularly in low- and middle-income countries. Shigellosis predominantly affects children under the age of five and is associated with high morbidity ...
Valentina Caradonna, Renzo Alfini, Marika Pinto, Roberta Di Benedetto, Carlo Giannelli, Donata Medaglini, Elena Pettini, Miren Iturriza, Omar Rossi, Francesca Micoli, Francesca Mancini   +10 more
doaj   +1 more source

RB49-like Bacteriophages Recognize O Antigens as One of the Alternative Primary Receptors. [PDF]

Int J Mol Sci, 2022
Efimov AD, Golomidova AK, Kulikov EE, Belalov IS, Ivanov PA, Letarov AV.   +5 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Identification of Antigens Specific to Non-Tuberculous Mycobacteria: The Mce Family of Proteins as a Target of T Cell Immune Responses

, 2011
The lack of an effective TB vaccine hinders current efforts in combating the TB pandemic. One theory as to why BCG is less protective in tropical countries is that exposure to non-tuberculous mycobacteria (NTM) reduces BCG efficacy.
Willem A Hanekom, Anna M Checkley, Wyllie, David H., Hill, Adrian, Thomas J Scriba, Hill Adrian V. S., Hanekom, Willem A., Thomas J. Scriba, McShane Helen, Hanekom Helen Mcshane, Willem A, Golubchik Tanya, Hanekom Willem A., Willem A. Hanekom, Hill, AV, Golubchik, Tanya, Anna M. Checkley, Helen McShane, Wyllie David H., Wyllie, DH, David H Wyllie, David H. Wyllie, Hanekom, WA, Scriba, Thomas J., Checkley Anna M., Scriba Thomas J., Hill, Adrian V. S., Scriba, TJ, Checkley, Anna M., Checkley, AM, Golubchik, T, Wyllie, David, Adrian V S Hill, Adrian V. S. Hill, Tanya Golubchik, McShane, H, McShane, Helen   +36 more
core   +1 more source

Avaliação hematológica e histopatológica de camundongos BALB/c e C57BL/6 expostos aos antígenos recombinantes Cytoplasmic Repetitive Antigen e Flagellar Repetitive Antigen de Trypanosoma cruzi Hematological and histopathological evaluation of BALB/c and C57BL/6 mice exposed to Cytoplasmic Repetitive Antigen and Flagellar Repetitive Antigen recombinant antigens of Trypanosoma cruzi

Revista da Sociedade Brasileira de Medicina Tropical, 2003
Os antígenos recombinantes Cytoplasmic Repetitive Antigen e Flagellar Repetitive Antigen de Trypanosoma cruzi foram inoculados em camundongos BALB/c e C57BL/6 e o seu efeito avaliado a nível hematológico e histopatológico.
Valéria Rêgo Alves Pereira, Virginia Maria Barros de Lorena, Ana Paula Galvão-da Silva, Mineo Nakazawa, Edimilson Domingos da Silva, Antonio Gomes Pinto Ferreira, Ulisses Montarroyos, Eridan de Medeiros Coutinho, Yara de Miranda Gomes   +8 more
doaj   +1 more source

Characterization of Enzyme-Linked Immunosorbent Assay (ELISA) for Quantification of Antibodies against Salmonella Typhimurium and Salmonella Enteritidis O-Antigens in Human Sera. [PDF]

BioTech (Basel), 2023
Aruta MG, Lari E, De Simone D, Semplici B, Semplici C, Dale H, Chirwa E, Kadwala I, Mbewe M, Banda H, Iturriza-Gomara M, Gordon M, Nyirenda T, Piu P, Pizza M, Berlanda Scorza F, Grappi S, Canals R, Rossi O, On Behalf Of The Vacc-iNTS Consortium Collaborators.   +19 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source