Results 101 to 110 of about 214,059 (308)

Duration of naturally acquired antibody responses to blood-stage Plasmodium falciparum is age dependent and antigen specific.

, 2008
Naturally acquired antibody responses provide partial protection from clinical malaria, and blood-stage parasite vaccines under development aim to prime such responses. To investigate the determinants of antibody response longevity, immunoglobulin G (IgG)
Conway, David J, Samuel Dunyo, Tetteh, Kevin KA, Dunyo, Samuel, Lanar, David E, Akpogheneta, Onome J, Margaret Pinder, Duah, Nancy O, Pinder, Margaret, David E. Lanar, David J. Conway, Onome J. Akpogheneta, Nancy O. Duah, Kevin K. A. Tetteh   +13 more
core   +1 more source

Host erythrocyte polymorphisms and exposure to Plasmodium falciparum in Papua New Guinea. [PDF]

, 2008
Contains fulltext : 69991.pdf (Publisher’s version ) (Open Access)BACKGROUND: The protection afforded by human erythrocyte polymorphisms against the malaria parasite, Plasmodium falciparum, has been proposed to be due to reduced ability
Pilling, L, Michon, P., Ripley, R.M., Luty, A.J.F., Fowkes, FJ, Luty, AJ, Mgone, CS, Fowkes Freya JI, Ripley, Ruth, Woods, C.M., Imrie Heather J, Ripley Ruth M, Imrie, H.J., Tavul Livingstone, Luty, AJF, Pilling Lynn, Fowkes, FJI, Michon, P, Fowkes, F.J., Day, K.P., Woods, CM, Woods Caira M, Tavul, L., Tavul, L, Ripley, RM, Pilling, L., Mgone Charles S, Day Karen P, Luty Adrian JF, Mgone, C.S., Imrie, HJ, Michon Pascal, Day, KP   +32 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Modification of H-2 Antigenic Sites by Enzymatic Treatment Influences Virus-Specific Target Cell Lysis [PDF]

, 1976
Vaccinia virus-infected cells were treated enzymatically to remove H-2 antigenic sites. The effect of this procedure on virus-specific cell-mediated cytolysis (CMC) and virus-specific antibody-mediated cytolysis (AMC) was tested. Due to the inhibition of
Ertl, H C, Koszinowski, Ulrich H., Koszinowski, U H, Ertl, H.   +3 more
core  

Enzymatic conversion of blood group B kidney prevents hyperacute antibody-mediated injuries in ABO-incompatible transplantation

Nature Communications
Matching ABO blood group antigens between donors and recipients is critical to prevent hyperacute rejection in kidney transplantation. Enzymatic conversion of blood group antigens to the universal O type presents a promising strategy to overcome barriers
Jun Zeng, Ming Ma, Xiaojuan Jiang, Zhengsheng Rao, Dan Huang, Hao Zhang, Saifu Yin, Rong Bao, Haohan Zhang, Zhiling Wang, Hongwei Gao, Feng Gong, Tao Lin, Keqin Zhang, Turun Song   +14 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity [PDF]

, 2011
<p><b>Background:</b> Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer).
Taracha, E. L. N., Mwangi Duncan M., Graham Simon P., Paul R. Spooner, Graham, S. P., Saya, RM, Toye, PG, Njahira, Moses N., Pelle, R., Richard P Bishop, Musoke, AJ, Silva, J., Rosemary M. Saya, Philip G Toye, Toye Philip G., Njahira, M.N., Saya, R. A., Evans L. N. Taracha, Musoke, A. J., Pelle Roger, Odongo, DO, Silva Joana C., Roger Pelle, Musoke Anthony J., Morrison, Ivan, Weir, W., Silva, J.C., Anthony J. Musoke, Joana C Silva, Graham, SP, Bishop, Richard P., Odongo, David O., Simon P Graham, Paul R Spooner, Taracha, EL, Morrison W. Ivan, Pelle, R, Bishop, R.P., Toye, P. G., Moses N Njahira, Saya Rosemary M., Duncan M. Mwangi, Spooner, P.R., Osaso Julius, Mwangi, D.M., W. Ivan Morrison, Toye, P.G., Silva, J. C., David O. Odongo, Osaso, J, Morrison, WI, Simon P. Graham, Moses N. Njahira, Mwangi, D. M., Evans L N Taracha, Taracha Evans L. N., Mwangi, DM, Odongo, D.O., Taracha, E.L.N., Bishop, RP, Morrison, W.I., Bishop, R. P., Njahira, M. N., Saya, R.M., Spooner, PR, Musoke, A.J., Saya, Rosemary M., Spooner, P. R., Richard P. Bishop, Pelle, Roger, Mwangi, David Miano, Spooner Paul R., Rosemary M Saya, Odongo David O., Njahira, MN, Joana C. Silva, Odongo, D. O., Duncan M Mwangi, Julius Osaso, W Ivan Morrison, Toye, Philip G., Njahira Moses N., Philip G. Toye, Morrison, W. Ivan, David O Odongo, Weir William, Bishop Richard P., Silva, JC, Osaso, J., Anthony J Musoke, Graham, S.P., William Weir, Weir, W   +92 more
core   +1 more source

Tumor-associated Tn and STn antigens: from molecular mechanism to precision diagnosis and treatment

Frontiers in Immunology
BackgroundAbnormal protein glycosylation is a key feature of tumors. Among the modifications, Tn antigen (GalNAcα1-Ser/Thr) and its sialylated derivative, STn antigen (Neu5Acα2-6GalNAcα1-O-Ser/Thr), are prominent tumor-associated carbohydrate antigens ...
Shuailong Zhao, Cegang Fu, Boya Gong, Hongyan Wu, Ruitao Zhang, Huili Cai, Haidan Chen, Haidan Chen   +7 more
doaj   +1 more source