Results 91 to 100 of about 205,716 (289)

Efficacy, Safety and PK of Once‐Daily Oral Semaglutide 25 mg for Obesity With and Without Type 2 Diabetes in Comparison With Subcutaneous Semaglutide 2.4 mg: A Model‐Informed Drug Development Approach

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Semaglutide has previously been approved for weight management and cardiovascular disease as a subcutaneous formulation, and more recently also as an oral formulation. However, there is limited information across oral dose levels, and there are no studies for the 25 mg dose in people with obesity and type 2 diabetes (T2D).
Rune Viig Overgaard, Oscar Birkhan, Naveen Rathor, Thomas Sparsø, Anders Strathe, Sean Wharton, Domenica Rubino   +6 more
wiley   +1 more source

Indirect Comparative Efficacy and Safety of Tirzepatide Versus Oral Semaglutide for the Treatment of Overweight and Obesity

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Tirzepatide, an injectable glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) receptor agonist (RA), is approved for weight management in several regions. Oral GLP‐1 RAs, such as semaglutide, are under investigation to improve convenience, acceptance and adherence versus injectable formulations ...
Andreea Ciudin, Erin Johansson, Sarah Zimner‐Rapuch, Georgios K. Dimitriadis, Mathias Hempfling, Laura J. Clark, Ludi Fan, Helene Sapin   +7 more
wiley   +1 more source

Estimated Oral Semaglutide Exposure Has Distinct Relationships With Glycaemic Response, Weight Loss and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Oral semaglutide absorption is subject to inter‐individual variability. We investigated whether estimated individual exposure (eCavg) provides predictive information beyond the prescribed dose in a real‐world cohort of patients with type 2 diabetes (T2D).
Gian Paolo Fadini, Mario Luca Morieri, Carlotta Boscaro, Benedetta Maria Bonora, Andrea Cignarella   +4 more
wiley   +1 more source

Legal status, sex work engagement and inequities in the HIV pre‐exposure prophylaxis cascade among migrant women in 11 European countries

HIV Medicine, EarlyView.
Abstract Background Migrant women account for a substantial proportion of new HIV diagnoses in Europe, yet remain underrepresented in HIV prevention research. Little is known about how legal status and national policy context shape engagement with PrEP among migrant women, particularly those without secure documentation.
Haoyi Wang, Anne Flaherty‐Gupta, Hala Majdoub, Edwin Sesange, Kim Isip, Justine Lubnow, Pedro Barrios Sanchez, Linda Pavanello, Etinosa Erevbenagie‐Johnbull, Lillian Petry, Emma Gooding, Magdalena Ankiersztejn‐Bartczak, Stavroula Triantafyllidou, Ann Piercy, Kai J. Jonas, Denis Onyango, Hanne M. L. Zimmermann, on behalf of the MiHealth HIV Partnership   +17 more
wiley   +1 more source

Organisational Factors and Nurses' Well‐Being in the Workplace: An Integrative Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To report organisational factors known to positively contribute to nurses' well‐being in the workplace. Design Integrative literature review. Methods Peer‐reviewed journal articles using various methodological approaches, and theoretical works, published in English with a focus on organisational factors and nurses' well‐being were included.
Carmel Bond, Rebecca Jarden, Adrianna Watson, Debra Jackson   +3 more
wiley   +1 more source

A Comprehensive Mapping of Intergenerational Caregiving: A Scoping Review of Dyadic and Family Caregiving

Journal of Family Theory &Review, EarlyView.
ABSTRACT Families remain central to later‐life support, yet evidence on intergenerational caregiving is fragmented across dyads, generations, and cultural contexts. This scoping review maps how caregiving is organized and negotiated across structural, associational, affectual, functional, consensual, and normative dimensions.
Chuen Wei Alvin Seah, Tin Mei Yeo, Zoe Jane‐Lara Hildon, Yong‐Shian Shawn Goh, Xin Hui Jasmine Chua, Jun Yi Claire Teo, Wenru Wang   +6 more
wiley   +1 more source

Characteristics of the Long‐Term Care Data Cooperative: A New Resource for Research on Outcomes in Long‐Term Care

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background The long‐term care (LTC) Data Cooperative is a National Institute on Aging‐funded data resource that links skilled nursing facility (SNF) electronic health record (EHR) data with Medicare and Medicaid claims for use in comparative effectiveness and interventional research.
Stephanie M. Kissam, Terry Hawk, Amy Recker, Catherine Rogers Murray, Dustin Burns, David D. Dore, David R. Gifford, Vincent Mor, Elizabeth M. White   +8 more
wiley   +1 more source

A posttranslational proteomic survey of a single anatomically preserved human 20‐week postconception brain

Journal of Anatomy, EarlyView.
A well‐preserved 20 post‐conception week human brain was obtained and finely dissected into 18 anatomically distinct regions, including the pia mater. Each region underwent in‐depth proteomic analysis, encompassing both total protein content and post‐translational modifications.
S. Bandiera, H. Bogetofte, P. Jensen, R. Hussain, S. A. Nischal, L. Rihova, G. J. Clowry, M. R. Larsen, Z. Molnár, B. C. Carlyle   +9 more
wiley   +1 more source

Pharmacokinetics of a Single Subcutaneous Extended‐Release Buprenorphine (Ethiqa XR) in Healthy Beagles

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT This study evaluated the pharmacokinetics of an extended‐release buprenorphine formulation (Ethiqa XR) in dogs and explored potential sex differences. Twelve healthy intact beagles (6 males and 6 females) received a single subcutaneous injection of Ethiqa XR (0.2 mg/kg).
Kornelia Tiffinger, Hiroko Enomoto, Ronald E. Baynes, Laura M. Neumann, B. Duncan X. Lascelles, Masataka Enomoto   +5 more
wiley   +1 more source

How Do They Feel? Processing Others’ Emotions in Second Language Discourse

Language Learning, EarlyView.
Abstract Emotion that is implied rather than literally expressed requires the processing of literal and pragmatic information. Processing multiple information types is an easy, fast process in the first language (L1) but can be costlier in a second language (L2), especially when emotional content is involved.
Andrea González‐García Aldariz, Eva M. Moreno, Alice Foucart   +2 more
wiley   +1 more source