Results 41 to 50 of about 63,674 (202)

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

open access: yesObesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey   +7 more
wiley   +1 more source

Novel epigenetic marks of insulin resistance trajectories in a longitudinal study of childhood obesity

open access: yesCardiovascular Diabetology
Background Childhood obesity is a major global public-health challenge. Insulin resistance (IR) is a critical driver of later cardiometabolic alterations.
Augusto Anguita-Ruiz   +11 more
doaj   +1 more source

Cold‐Induced Lipidomic Remodelling Is Associated With Brown Adipose Tissue Mean Radiodensity in Humans

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5810-5826, July 2026.
ABSTRACT Aims Cold exposure activates brown adipose tissue (BAT) and promotes thermogenic and metabolic adaptations. While BAT activation has been linked to improved cardiometabolic health, how acute cold exposure reshapes the circulating lipidome in humans remains incompletely understood.
Yu Zhang   +7 more
wiley   +1 more source

Obesidad y sobrepeso en adultos de 35–60 años de la parroquia Valdez – Limones

open access: yes, 2017
Tesis previa obtención del título de Licenciado/a en EnfermeríaPara el desarrollo de esta investigación se planteó como objetivo determinar la prevalencia de obesidad y sobrepeso en adultos de 35 a 60 años de edad del barrio Cali parroquia Valdez ...
Caicedo Caicedo, Yarissa Ines
core   +1 more source

Mechanisms linking excess adiposity and carcinogenesis promotion

open access: yesFrontiers in Endocrinology, 2014
Obesity constitutes one of the most important metabolic diseases being associated to insulin resistance development and increased cardiovascular risk. Association between obesity and cancer has also been well-established for several tumor types, such as ...
Ana I. Pérez-Hernández   +9 more
doaj   +1 more source

Integrated miRNA–mRNA Analysis Reveals Obesity‐Driven Regulatory Networks in Human Visceral Adipose Tissue With and Without Type 2 Diabetes

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5992-6008, July 2026.
ABSTRACT Aims Obesity is characterised by pathological alterations in visceral white adipose tissue (vWAT) that may contribute to the development of type 2 diabetes (T2D). While microRNAs (miRNAs) are key post‐transcriptional regulators, comprehensive human vWAT profiling across metabolic states remains limited.
Elsa Villa‐Fernández   +19 more
wiley   +1 more source

Obesidad y enfermedad renal crónica. Una mirada desde los mecanismos fisiopatológicos.

open access: yesREV SEN, 2022
Introducción: La enfermedad renal crónica asociada a la obesidad (ERCO) es una enfermedad con aumento en la prevalencia en las últimas décadas. Se caracteriza por un exceso de desequilibrios hormonales adipocíticos (adipoquinas), desregulación del ...
Jorge Rico-Fontalvo   +8 more
doaj   +1 more source

Increased Brown Adipose Tissue Thermogenesis in Phenylketonuria

open access: yesMedComm, Volume 7, Issue 6, June 2026.
In phenylketonuria (PKU), elevated phenylalanine (Phe) increases hepatic fibroblast growth factor 21 (FGF21) and thyroid hormones, enhancing brown adipose tissue (BAT) thermogenesis in patients. Central FGF21 reproduces this phenotype in rodents via reduced hypothalamic AMP‐activated protein kinase (AMPK) activity in the ventromedial nucleus of the ...
Noemí López‐Rey   +18 more
wiley   +1 more source

Creencias en obesidad y cirugía bariátrica: análisis de contenido para diseñar una escala

open access: yes, 2021
El objetivo de este estudio fue describir el proceso por el cual se generaron los ítems de una escala de creencias en obesidad y cirugía bariátrica mediante métodos mixtos. Participaron 22 pacientes bariátricos, ecuatorianos entre 22 y 50 años (M = 37.5,
González Guerra, María Victoria
core   +1 more source

Longitudinal association of changes in diet with changes in body weight and waist circumference in subjects at high cardiovascular risk: the PREDIMED trial

open access: yesInternational Journal of Behavioral Nutrition and Physical Activity, 2019
Background Consumption of certain foods is associated with long-term weight gains and abdominal fat accumulation in healthy, middle-aged and young, non-obese participants.
Jadwiga Konieczna   +19 more
doaj   +1 more source

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