Results 161 to 170 of about 3,071,426 (354)

The causes of childhood obesity: A survey [PDF]

Childhood obesity rates are rapidly rising in many countries. Since it is highly likely that obesity will persist into adulthood, current rates undermine the health and future of people in developed as well as developing countries.
Drichoutis, Andreas, Nayga, Rodolfo, Papoutsi, Georgia   +2 more
core   +1 more source

CRISPR‐MI and scRNA‐Seq Reveal TREM2's Function in Monocyte Infiltration and Macrophage Apoptosis During Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
A method is developed for conducting genome‐wide CRISPR/Cas9 screening of monocyte infiltration in vivo (CRISPR‐MI) that is easily adaptable across a variety of disease models. Through the combination of CRISPR‐MI and scRNA‐Seq, this study discovers that Trem2 is a key regulator of early monocyte infiltration in abdominal aortic aneurysm (AAA ...
Haocheng Lu, Chao Xue, Yang Zhao, Jinjian Sun, Changzhi Zhao, Xu Zhang, Guizhen Zhao, Yaozhong Liu, Hongyu Liu, Yongjie Deng, Ying Wang, Chi Zhang, Yingjie Liu, Linjun Zeng, Ying Yang, Bolun Li, Shusi Ding, Linkang Zhou, Henry Kuang, Zanxin Wang, Wenhao Ju, Haihuan Lin, Jie Lin, Yanhong Guo, Lin Chang, Hongmei Zhao, Jing Wang, Jiandie Lin, Lemin Zheng, Y. Eugene Chen, Jifeng Zhang   +30 more
wiley   +1 more source

Therapeutic targeting of obesity-induced neuroinflammation and neurodegeneration [PDF]

Jialiu Zeng, Lenny Yi Tong Cheong, Chih Hung Lo   +2 more
openalex   +1 more source

Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010.

Journal of the American Medical Association (JAMA), 2012
K. Flegal, M. Carroll, Brian K. Kit, Cynthia L Ogden   +3 more
semanticscholar   +1 more source

Obesity‐Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis

Advanced Science, EarlyView.
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang, Chong Yang, Dayuan Luo, Pingting Liu, Zhen Zeng, Weilin Peng, Dongzi Peng, Hao Su, Xiaoxiong Xiao, Haiqin Wang, Xin Jin   +10 more
wiley   +1 more source

Lnc‐HZ05 Suppresses Trophoblast Cell Migrasome Formation by Disrupting TGFβ2 Pathway in Unexplained Recurrent Miscarriage

Advanced Science, EarlyView.
TGFβ2 signaling‐mediated migration/invasion and migrasome formation are suppressed in recurrent miscarriage (RM) versus healthy control villous tissues and are negatively associated with unexplained RM. In mechanism, TGFβ2 promotes trophoblast cell migration/invasion and migrasome formation, all of which are suppressed by lnc‐HZ05. In details, lnc‐HZ05
Weina Chen, Ying Zhang, Zimeng Zhao, Yang Yang, Geng Guo, Yi Sun, Tao Zhang, Zhihong Zhang, Liqin Zeng, Wenxin Huang, Qingjun Shen, Ruining Han, Zhaohui He, Depeng Zhao, Huidong Zhang   +14 more
wiley   +1 more source

Data_Sheet_4_Resolvin E1-ChemR23 Axis Regulates the Hepatic Metabolic and Inflammatory Transcriptional Landscape in Obesity at the Whole Genome and Exon Level.XLSX

, 2021
Abrar E. Al-Shaer (6580940), Anandita Pal (11876804), Saame Raza Shaikh (4178581)   +2 more
openalex   +2 more sources

Oral Celastrol Micelles Forming High‐Density Lipoprotein Corona Targeting Hepatocytes for MASLD Treatment

Advanced Science, EarlyView.
Upon oral administration, OPDEA‐PCL/CEL micelles passed through the stomach acid intact, then quickly penetrated the intestinal mucus and transported into circulation, where they captured HDL to form a protein corona and target hepatocyte SR‐B1 receptors, inducing endocytosis.
Chang Xu, Haoru Zhu, Kai Wang, Haitao Hu, Xuyong Wei, Dongdong Xu, Jing Zhang, Yanpeng Liu, Jun Chen, Youqing Shen, Nasha Qiu, Xiao Xu   +11 more
wiley   +1 more source

Effects of an intensive inpatient rehabilitation program in elderly patients with obesity [PDF]

, 2019
Berteotti, M., BIGOLIN, FRANCESCO, Budui, S., Busetto, L., Castiglioni, F., Franceschini, L., Gilli, F., Giordano, F., Leoni, S., Letizia Petroni, M., Salvetti, S., Sartori, E., SCHENA, FEDERICO, Skafidas, S., Taddei, M.   +14 more
core   +1 more source

Interaction between Age and Obesity on Cardiomyocyte Contractile Function: Role of Leptin and Stress Signaling

, 2010
Jun Ren, Feng Dong, Guojun Cai, Peng Zhao, Jennifer M. Nunn, Loren E. Wold, Jianming Pei   +6 more
openalex   +2 more sources