Results 151 to 160 of about 1,339,496 (303)

Anti-obesity agents

, 2017
Obesity is a preventable complex multifactorial disease. With the steady and rapid progression of obesity trends in the past few decades, it has become a global epidemic.
Kourouniades, Stavros
core  

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Obesity and Developmental Functioning Among Children Aged 2-4 Years [PDF]

In developed countries, obesity tends to be associated with worse labor market outcomes. One possible reason is that obesity leads to less human capital formation early in life.
John Cawley, C. Katharina Spieß
core   +2 more sources

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

Trends in Atrial Fibrillation-Related Mortality Among Adults With Obesity in the United States From 1999 to 2024. [PDF]

Obes Sci Pract
Ahmed A, Batool RM, Waqas SA, Siddiqui HF, Arshad MS, Paryani NS, Shahid I, Aminpoor H, Mithani A, Ayub MT.   +9 more
europepmc   +1 more source

Obesity: pathophysiology and treatment

, 2017
Obesity is a complex, multifactorial condition characterized by excess body fat. It is one of the leading preventable causes of death worldwide. It must be viewed as a chronic disorder.
Schwarzmann, Liran
core  

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

Vaccinating People with Obesity for COVID-19: EASO Call for Action

Obesity Facts, 2021
Dror Dicker, Rachel Golan, Jennifer Lyn Baker, Luca Busetto, Gema Frühbeck, Gijs H. Goossens, Jason C.G. Halford, Jens-Christian Holm, Euan Woodward, Nathalie J. Farpour-Lambert   +9 more
doaj   +1 more source

Socioeconomic development, longevity and prevalence of obesity and overweight: The retrospective longitudinal analysis of international data. [PDF]

Dialogues Health
Liapin G, Vlassov V.
europepmc   +1 more source

Fat City: The Relationship Between Urban Sprawl and Obesity [PDF]

We study the relationship between urban sprawl and obesity. Using data that tracks individuals over time, we find no evidence that urban sprawl causes obesity.
Henry G. Overman, Matthew A. Turner, Jean Eid, Diego Puga   +3 more
core