Results 91 to 100 of about 454,476 (312)

Relation between cost of drug treatment and body mass index in people with type 2 diabetes in Latin America [PDF]

, 2017
Aims Despite the frequent association of obesity with type 2 diabetes (T2D), the effect of the former on the cost of drug treatment of the latest has not been specifically addressed.
Enzo Rucci, Jorge Federico Elgart, Juan Jose Gagliardino, Lorena Gonzalez, Mariana Prestes, null null   +5 more
core   +2 more sources

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Obesity as a risk factor following cadaveric renal transplantation [PDF]

, 1990
Obesity has generally been thought to increase the risk of operative mortality and postoperative complications in surgical patients. No data examining obesity as a factor in cadaveric renal transplantation were available.
Hakala, TR, Holley, JL, Lopatin, WB, Shapiro, R, Starzl, TE, Tzakis, AG   +5 more
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Laparoscopic Surgery for Obesity

Asian Journal of Surgery, 2006
The sobering facts are that over one-third of the population of the United States is overweight and one-fifth is obese as defined as a body mass index (BMI) ≥ 30 kg/m2 (Table 1). As a society, Americans spend over 140 billion healthcare dollars trying to treat the epidemic.
openaire   +4 more sources

The Benefit of Sleeve Gastrectomy in Obese Adolescents on Nonalcoholic Steatohepatitis and Hepatic Fibrosis [PDF]

, 2017
Objective To determine whether bariatric surgery is effective for the treatment of nonalcoholic steatohepatitis (NASH) in adolescence, we compared the efficacy of laparoscopic sleeve gastrectomy (LSG) with that of lifestyle intervention (nonsurgical ...
Alisi, Anna, Baumann, Ulrich, Caccamo, Romina, Cutrera, Renato, De Peppo, Francesco, De Stefanis, Cristiano, Giordano, Ugo, Manco, Melania, Mosca, Antonella, Nobili, Valerio, Silecchia, Gianfranco   +10 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

The multimodal approach to obesity treatment – current pharmacological and surgical methods and lifestyle changes

Journal of Education, Health and Sport
Introduction            Obesity is one of the major health problems of today’s population and is defined as a body mass index ≥ 30 kg/m2.  It is known that obesity may cause many complications such as type 2 diabetes, cardiovascular disease ...
Maria Kowalczuk, Justyna Lipińska, Izabela Kopeć, Łukasz Lipiński, Jakub Kamiński, Klaudia Klimczak, Laura Loryś, Marcin Narloch, Stanisław Kasprzak, Karolina Kasprzak   +9 more
doaj   +1 more source

Incisional hernia risk in intracorporeal anastomosis with Pfannenstiel incision versus extracorporeal anastomosis with midline incision for laparoscopic right hemicolectomy: a multicenter comparison [PDF]

Annals of Coloproctology
Purpose Laparoscopic right hemicolectomy can be performed via intracorporeal ileocolic anastomosis (ICA) or extracorporeal ileocolic anastomosis (ECA). Prior studies have emphasized ICA’s advantages in hospital stay and postoperative pain.
Francesco Saverio Lucido, Giusiana Nesta, Luigi Brusciano, Claudio Gambardella, Francesco Pizza, Giuseppe Scognamiglio, Gianmattia del Genio, Salvatore Tolone, Federico Maria Mongardini, Massimo Mongardini, Ludovico Docimo, Simona Parisi   +11 more
doaj   +1 more source

Aspiration therapy for the treatment of obesity: 4-year results of a multicenter randomized controlled trial. [PDF]

, 2019
BackgroundThe AspireAssist is the first Food and Drug Administration-approved endoluminal device indicated for treatment of class II and III obesity.ObjectivesWe earlier reported 1-year results of the PATHWAY study.
Abu Dayyeh, Barham K, Amaro, Anastassia, Apovian, Caroline, Aronne, Louis J, Bohning, J Matthew, Early, Dayna, Edmundowicz, Steven A, Goldsmith, Heidi, Haas, Miki, Jaffe, David L, Jensen, Michael D, Jirapinyo, Pichamol, Kim, Dong Wook, Kushner, Robert F, Kushnir, Vladimir, Lowe, Abigail, McCrea, Jennifer, Ryan, Michele B, Schorr, Alan B, Schulman, Allison R, Sharaiha, Reem, Shukla, Alpana P, Stein, Adam C, Sullivan, Shelby, Thompson, Christopher C, Tran, Daniel, Young, Meredith, Zarrinpar, Amir   +27 more
core