Results 71 to 80 of about 3,225,497 (280)

The Knowable and the Ineffable: an object-oriented reading of Enric Miralles’ design approach

Cuadernos de Proyectos Arquitectónicos, 2019
Abtract This paper links the current philosophical stance of Object-oriented Ontology (OOO) to Enric Miralles’ design approach in the late 20th century.
Gonzalo Vaíllo
doaj   +1 more source

A formal model of the Semantic Web Service Ontology (WSMO) [PDF]

, 2012
Semantic Web Service, one of the most significant research areas within the Semantic Web vision, has attracted increasing attention from both the research community and industry.
Payne, T.R., Nick Gibbins, Wang, H.W., Redavid, D., Hai H. Wang, Wang, Hai, Gibbins, Nick, Payne, Terry, Terry R. Payne, Gibbins, N., Redavid, Domenico, Domenico Redavid, Redavid D., Gibbins N., Payne T. R., Wang H. H.   +15 more
core   +1 more source

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian, Teizo Yoshimura, Kun Zhao, Chunning Li, Tong Gao, Ziyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Akihiro Matsukawa   +8 more
wiley   +1 more source

Rethinking Organismic Unity: Object-Oriented Ontology and the Human Microbiome

Open Philosophy
In recent years, a vast array of thinkers have been invested in challenging the long-standing binary division between the human and nonhuman. The notion of the human microbiome especially attests to the truth of such a complication, since current ...
Young Niki, Lanfranco Sandro
doaj   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

“Get the Tone Right”: Reading with the Realism of Object-Oriented Ontology

Open Philosophy, 2018
This paper investigates the consequences of taking seriously the metaphysics of Object-Oriented Ontology (OOO), as defined by Graham Harman, in the field of literature. Acutely focusing on just one possible mobilisation and application of the theory, the
Wei-Hao Chin Gabriel Patrick
doaj   +1 more source

Chrysanthemum Morifolium–Derived Nanovesicles Reduce Lactate‐Associated Histone Lactylation and Modulate Microglia‐Mediated Neuroinflammation in Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
When used to treat sepsis‐associated encephalopathy, Chrysanthemum morifolium–derived nanovesicles can inhibit the H3K18la/NF‐κB axis to regulate microglia‐mediated neuroinflammation. ABSTRACT Sepsis‐associated encephalopathy (SAE)—a complication of the central nervous system in patients with sepsis—markedly diminishes cognitive functions and is linked
Kaiqiang Li, Xuling Luo, Xiaoting Zhang, Chengwen He, Wei Xu, Aibo Xu, Shushan Hua, Liping Wang, Liang Ma, Ke Hao, Youmin Ying, Zhen Wang   +11 more
wiley   +1 more source

Objects, Relations, Potential and Change

Open Philosophy, 2020
This article attempts to develop further the conception of dynamics in Object-Oriented Ontology (OOO): its model of how objects develop and change. Objects are affected by relations between them, and have the potential both to produce and undergo effects,
Nooteboom Bart
doaj   +1 more source

Advancing European Plant Variety Registration: Data‐Driven Insights and Stakeholder Perspectives

Agribusiness, EarlyView.
ABSTRACT Efficient plant variety registration is crucial for fostering innovation in the European Union, yet the current regulatory framework is complex and faces calls for reform. This study provides data‐driven evidence to inform the ongoing legislative debate by employing a mixed‐methods approach.
Sergio Urioste Daza, Ibtissem Taghouti, José María Gil Roig   +2 more
wiley   +1 more source

ONTOLOGICAL FRAMEWORK FOR OBJECT-ORIENTED ANALYSIS AND DESIGN [PDF]

American Journal of Engineering and Applied Sciences, 2012
Regardless of the large number of Object-Oriented (OO) modeling languages currently being used in the Information Systems (IS) modeling process, unavailability of an OO modeling language that can be used in both the analysis and design phases disintegrates the two phases.
openaire   +1 more source