Results 51 to 60 of about 2,375,655 (290)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Attachment and alexithymia: the role of emotions from the affective deprivation towards illness

Mediterranean Journal of Clinical Psychology, 2014
 A growing body of evidence investigated the relationship between alexithymia and attachment styles. Particularly, the attachment model suggests that repeated crucial stressful interactions, such as trauma, can increase the vulnerability to illness in ...
Valentina Leonardi, Marialetizia Caracciolo, Domenico Mallamace   +2 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Effect of Skin to Skin Contact between the Biological Mother and Their Baby Who Born Via Surrogacy on Mother Infant Attachment

Iranian Journal of Nursing and Midwifery Research
Background: The attachment between mother and infant, beginning from pregnancy and reaching a peak with skin-to-skin contact, has a considerable effect on infants’ growth and development. As stress and anxiety in contact with infants and unwillingness to
Robabe M. Disfani, Jila Mirlashari, Shima Younespour, Shima Y. Tirandaz, Jamalodin Begjani   +4 more
doaj   +1 more source

The Role of Animacy and Structural Information in Relative Clause Attachment: Evidence From Chinese

Frontiers in Psychology, 2019
We report one production and one comprehension experiment investigating the effect of animacy in relative clause attachment in Chinese. Experiment 1 involved a fill-in-the-blank task that manipulated the order of an animate noun phrase in a complex NP ...
Nayoung Kwon, Deborah Ong, Hongyue Chen, Aili Zhang   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Adolescent Twins’ Mental Representations of Self and Other in Relation with Zygosity, Attachment Patterns and Psychological Disturbances [PDF]

, 2015
Introduction: Based on a theoretical integration of cognitive development psychology, psychoanalytic theory and attachment theory, Blatt and his colleagues formulated a systematic psychodynamic model of mental representation of self and other emphasizing
Zhou, Y
core  

Maternal-Fetal attachment in unplanned pregnancies following an antenatal training program: A Randomized Clinical Trial [PDF]

Journal of Research Development in Nursing and Midwifery
Background: Women have less interaction with the fetus in unplanned pregnancies. This study aimed to determine the effect of an antenatal training program on maternal-fetal attachment in unplanned pregnancies.
Parastou Mahmoudi, Marjan Ahmad Shirvani, Forouzan Elyasi, Aliasghar Nadi   +3 more
doaj  

Object attachment and the critical period [PDF]

Psychonomic Science, 1967
Well past normally accepted critical periods, social isolation and darkness appear to contribute to the process that leads to a bird-object attachment.
openaire   +1 more source