Results 111 to 120 of about 1,105,657 (336)
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
, 2011 With the technological evolution of digital acquisition and storage technologies, millions of images and video sequences are captured every day and shared in online services. One way of exploring this huge volume of images and videos is through searching a particular object depicted in images or videos by making use of object duplicate detection ...
openaire +2 more sources
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
A Survey of UAV Visible-Light Object Detection Based on Deep Learning [PDF]
Hangkong bingqiWith the rapid development of artificial intelligence, visible-light object detection, as an important part of computer vision technology, has been widely used in the unmanned aerial vehicle (UAV) reconnaissance field.
Liu Keshun, Zuo Xiaotong, Zhang Yuhua, Wang Changlong, Yang Sen
doaj +1 more source
Deformable Capsules for Object Detection
Advanced Intelligent SystemsCapsule networks promise significant benefits over convolutional neural networks (CNN) by storing stronger internal representations and routing information based on the agreement between intermediate representations’ projections. Despite this, their success has been limited to small‐scale classification datasets due to their computationally expensive ...
Rodney LaLonde +2 more
openaire +4 more sources
FEBS Letters, EarlyView.Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia +5 more
wiley +1 more source
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
, 2019 Technical Report / Hochschule Bonn-Rhein-Sieg University of Applied Sciences.
openaire +2 more sources