Results 171 to 180 of about 23,660,772 (290)

Quality of Life of People Living With Dementia Residing in Nursing Homes: Secondary Analysis of Observational Data. [PDF]

J Med Internet Res
Steijger D, Scheper MC, van der Willigen RF, Christie H, de Vugt ME, Verbeek H, Aarts S.   +6 more
europepmc   +1 more source

Objective Well-being Indicators and Subjective Well-being Measures: How important are they in current public policy?

, 2020
The use of GDP as an indicator of social progress and quality of life has been challenged since the last quarter of the 20th century. The publication of the Stiglitz-Sen-Fitoussi Commission Report in 2009 was decisive in highlighting the limitations of GDP and in confirming the need to shift focus from measuring economic production to measuring people ...
openaire   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Artificial Intelligence and Social Well-Being in the Yellow River Basin: A Cultural Lag Theory Perspective

Amid comprehensive reforms, artificial intelligence (AI) has emerged as a vital force in solving people’s problems and enhancing quality of life. Yet, theoretical inquiries into the mechanisms by which AI influences social well-being remain limited.
Shuoxun Cheng, Guanying Wang, Zhaoxin Song, Yongfeng Duan   +3 more
core   +1 more source

Is social work effectiveness related to the well-being of older adults in rural China? A moderated mediation model of social support and self-governance awareness. [PDF]

Front Public Health
Zhou J, Xia H, Zhou Y, Zuo S, Bao S.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Exam Scheduling Preferences and Their Impact on Student Well-Being and Performance: A Call for Objective Evaluation and Supportive Interventions [Letter]

Advances in Medical Education and Practice
Talal El-Jabri, Obaid Rahman, Ameer Hamid A Khan Addenbrooke’s Hospital, Cambridge University Hospitals NHS Trust, Cambridge, UKCorrespondence: Talal El-Jabri, Cambridge University Hospitals NHS Trust, Cambridge, UK, Email talal.el-jabri1@nhs ...
El-Jabri T, Rahman O, Khan AHA
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source