Results 161 to 170 of about 1,532,385 (249)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
A Practical Guide to Bayesian Optimization for Organic Chemists. [PDF]
Chem CatalShey R, Roediger S, Doyle AG, West J.
europepmc +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Rationality Criteria for Complex Goal Systems: The case of the EU Water Framework Directive. [PDF]
Environ ManageDoorn N +2 more
europepmc +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Speciality grand challenge: next steps for coaching? Some existing and emerging issues
Frontiers in Sports and Active LivingDave Collins, Dave Collins, Dave Collins
doaj +1 more source
Unlocking Knowledge: Designing an Infectious Diseases-Themed Escape Room for Medical Student and Resident Education. [PDF]
Open Forum Infect DisKeintz MR +3 more
europepmc +1 more source