Results 171 to 180 of about 1,662,166 (403)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

On Necessity in Cypriot Turkish

open access: yesDilbilim Araştırmaları Dergisi, 2015
This paper focuses on the expression of necessity as a modal notion in Cypriot Turkish. A qualitative analysis of data gathered from various sources reveals that periphrastic or lexical expressions such as mecbur‘obliged,’ lazım ‘necessary,’ illa ...
Mine Güven
doaj  

"Empirical Analysis of the National Treatment Obligation Under the WTO: The Case of Japanese Shochu " [PDF]

open access: yes
The national treatment obligation, along with the most favored nation obligation, is an important principle of non-discrimination adopted by theWorld Trade Organization.
Hiroshi Ohashi, Naoshi Doi
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

THEORETICAL ISSUES REGARDING THE JUSTIFIABLE CAUSE FOR EXERCISING A RIGHT OR FULFILLING AN OBLIGATION [PDF]

open access: yesChallenges of the Knowledge Society
The review of the legal background, based on which was inserted in the time-specific normative acts, the justifiable cause under study indicates the legislator’s concern to provide some provisions removing the unjustifiable character of a criminal act ...
Alin-Sorin NICOLESCU   +1 more
doaj  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

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