Results 191 to 200 of about 379,306 (343)

Realizing human rights in rural Punjab of India: a study of enforcement of selected human rights. [PDF]

Front Sociol
Pathak P, Nandini V, Yadav D, Kaur S, Sen RK, Riang S.   +5 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Regulation of phage therapy medicinal products: developments, challenges, and opportunities. [PDF]

Front Cell Infect Microbiol
Fuerst-Wilmes M, Respondek V, Schramm M, Lilienthal N, Buss K, Duechting A.   +5 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Learning Challenges and Motivations of Medical Students in Japan's Regional Quota System: A Qualitative Study From Okinawa Prefecture. [PDF]

Cureus
Yara M, Kakazu R, Hiyajo Y, Machida H, Kinjo K, Ohta R.   +5 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Co-curricular engagement, moral quotient, and pro-environmental behaviors of university students in Bangladesh. [PDF]

BMC Psychol
Shahrier MA, Kayesh KI, Zubaier AM, Khan RA, Sarkar N, Rahman ML.   +5 more
europepmc   +1 more source

The challenges of the landing obligation in EU fisheries

, 2017
T. Catchpole, Ana Ribeiro-Santos, S. Mangi, C. Hedley, T. Gray   +4 more
semanticscholar   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Bioeconomic multistock reference points as a tool for overcoming the drawbacks of the landing obligation

, 2017
D. Garcia, R. Prellezo, Paz Sampedro, José-María Da-Rocha, J. Castro, S. Cerviño, Javier García-Cutrín, Maŕıa-José Gutiérrez   +7 more
semanticscholar   +1 more source