Results 61 to 70 of about 86,695,143 (250)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
We provide a characterization of the obligation rules in the context of minimum cost spanning tree games. We also explore the relation between obligation rules and random order values of the irreducible cost game - it is shown that the later is a subset ...
Gustavo Bergantiños, Anirban Kar
core
Justice, community and obligation: a study of recent liberal political philosophy [PDF]
, 1990 Liberals disagree about the state's legitimate sphere of activity. Some emphasise individual liberty and self-determination, believing the requirements of these principles are best met by the free market.
McCarthy, A, McCarthy, Austin
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Genealogy of Early Islamic Traditions: A Study of Hadith on the Honour of Time [PDF]
Pharos Journal of TheologyThis research addresses the genealogy of early Islamic traditions with a focus on the study of hadith traditions which refer to a collection of traditions containing utterances of the prophet Muhammad which, along with accounts of his daily practice (the
Revi Fauzi Putra Mina +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Inter-Environnement Expanded: Another Brick Out of the Wall of EU Law Supremacy?
European Papers, 2017 (Series Information) European Papers - A Journal on Law and Integration, 2017 2(1), 321-327 | European Forum Insight of 29 March 2017 | (Table of Contents) I. Introduction. - II. The legal and factual background of the case. - III.
Giulia Gentile
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Anuario de Derechos Humanos, 2015 This article presents arguments about the international responsibility of the Chilean State derived from the fire occurred in the San Miguel Prison, in which 81 internees died and other 13 result severely injured.
Karinna Fernández Neira +1 more
doaj +1 more source