Results 71 to 80 of about 1,388,590 (311)
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
STUDY ON THE OBJECTIVE NOVATION OF AN OBLIGATION [PDF]
Challenges of the Knowledge Society, 2017 In view of the fact that there is no consensus among the authors not only with regard to the precise nature, but also with regard to the unitary or dual character of the effects stemming from novation, we have decided to prepare a study on the novation ...
Ioan Lucian MARINESCU
doaj
COMPENSATION FOR DAMAGES IN CASE OF VIOLATION OF CONTRACTUAL OBLIGATIONS BY MEMBERS OF GROUPS OF LEGAL ENTITIES [PDF]
Legal BulletinRelevance: due to the widespread use of groups of legal entities as a key element of the modern economy, there is an increasing need for comprehensive legal regulation of intra-group contractual relations and regulation of the specifics of ways to ...
MUTAFYAN GEORGIY
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Unilateral Termination of Contracts Between Suppliers and Consumers [PDF]
Risk in Contemporary Economy, 2012 At present there is a special concern for the consumer’s protection. The right of unilateral termination confers to one of the contracting parties the possibility to decide over keeping and executing the contract without the other party's consent.
Doina UDRESCU, Monica COCOR
doaj
Taking One for the Team: Legal Consequences of Misconduct by Partners
Scandinavian Journal of Military Studies, 2020 As Nordic states and their allies embark on ever more challenging military operations abroad, the complexity of the applicable rules – and legal consequences they may have – is growing rapidly.
Cornelius Wiesener
doaj +1 more source
Benefiting from injustice and brute luck [PDF]
, 2013 Many political philosophers maintain that beneficiaries of injustice are under special obligations to assist victims of injustice. However, the examples favored by those who endorse this view equally support an alternative luck egalitarian view, which ...
Knight, C.
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
, 2014 The moral obligation to obey the law, or as it is generally called, political obligation, is a moral requirement to obey the laws of one’s country. Traditionally, this has been viewed as a requirement of a certain kind, to obey the law because it is the law, as opposed to the content of particular laws.
openaire +1 more source