Results 41 to 50 of about 327,761 (348)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Heuristic Solution Algorithm for a Comprehensive Optimal Phasor Measurement Unit Placement Considering Zero-Injection Buses and Practical Constraints in Power System State Observability Problem

IEEE Access
Accurate power system observability relies on the optimal phasor measurement unit (PMU) placement to minimize costs while ensuring complete state observability. However, modeling the effect of zero-injection (ZI) buses remains a key challenge.
Sayed Hamid Hosseini Dolatabadi, Tanveer Hossain Bhuiyan, Mohammad Esmail Hamedani Golshan   +2 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

On the placing of synchronized vector measurements in network 110 - 330 kV for identification of the Kaliningrad region power system regime

E3S Web of Conferences, 2018
A solution is presented for the problem of placing phasor measurement unit to identify the mathematical model of the electric power system in the state space. The criterion for complete observability of the Kalman dynamic system is taken as a basis. As a
Gadzhiev Magomed, Gulevich Eugenia, Korobka Vyacheslav, Ryabchenko Vladimir, Sharov Yuriy   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Data‐driven observability analysis and enhancement for radome slope estimation with constraints on impact angle and terminal acceleration

IET Radar, Sonar & Navigation
The authors address the problem of observability analysis and enhancement for missiles equipped with strapdown seekers, especially considering the line‐of‐sight angle‐only measurements and the constraints on impact angle and terminal acceleration. First,
Bingyu Jin, Kelin Lu, Yuping Lu
doaj   +1 more source

Controllability and Observability of Fractional Linear Systems with Two Different Orders

The Scientific World Journal, 2014
This paper is concerned with the controllability and observability for a class of fractional linear systems with two different orders. The sufficient and necessary conditions for state controllability and state observability of such systems are ...
Dengguo Xu, Yanmei Li, Weifeng Zhou
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Cost-Profiling Microservice Applications Using an APM Stack

Future Internet, 2023
Understanding how the different parts of a cloud-native application contribute to its operating expenses is an important step towards optimizing this cost.
Sjouke de Vries, Frank Blaauw, Vasilios Andrikopoulos   +2 more
doaj   +1 more source