Results 141 to 150 of about 495,030 (294)

When Distress Goes Unseen: Mental Health Recognition Failures in Language-Discordant Consultations. [PDF]

Healthcare (Basel)
Pena-Díaz C, García Santiago FA.
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Observable signs of concussion in professional slap fighting using established video review protocols for professional sports: frequency, predictors, and implications for public concussion recognition awareness. [PDF]

PeerJ
Stewart CJ, Philipson EB, Caspell JR, Gorman K, Marshall RA, Lifshitz J.   +5 more
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Is entropy objective? Rethinking the foundations of irreversibility and the second law. [PDF]

PNAS Nexus
Parrondo JMR.
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Platonic Projection Structures: Operator-Induced Observability in Representation Learning. [PDF]

Entropy (Basel)
Ishii K, Gautam BP, Wu J, Saher J.
europepmc   +1 more source

Working with the non-observable: audio-visual modes of doing and undoing knowledge [Visual Anthropology Network (VANEASA) Panel]

Considering that the term and concept of ‘theory’ derive from the Greek word theorein, meaning ‘to look at,’ to ‘contemplate,’ to ‘speculate,’ this panel asks how non-observable realities can be grasped and theorised through audio-visual means.
Favero, Paolo, Torresan, Angela
core  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Extreme Event Aware (η-) Learning. [PDF]

Nat Commun
Chang K, Sapsis TP.
europepmc   +1 more source