Results 151 to 160 of about 1,614,365 (286)

Measuring health-related quality of life in infants and toddlers: conceptual challenges and proposed recommendations. [PDF]

Qual Life Res
Powell PA, Rencz F, Carlton J, Schieskow S, Peasgood T, Mulhern B, Finch A, Herdman M, Verstraete J.   +8 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Quantifying observable movement reserve in multiple sclerosis via upper diurnal activity quantiles. [PDF]

Mult Scler
Guha Niyogi P, Sanjayan M, Ghosal R, Goldsmith J, Fitzgerald KC, Mowry EM, Zipunnikov V.   +6 more
europepmc   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A methodology for integrating AI into embodied human intelligence for the performance of complex tasks. [PDF]

Front Artif Intell
Ahmed T, Rikakis T.
europepmc   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Coalgebras for modelling observable behaviour of programs

Journal of Applied Mathematics and Computational Mechanics, 2017
William Steingartner, Valerie Novitzká
doaj   +1 more source

Advancing observer-reported outcome measurement: development of the MOOD-AS for observing distress in Angelman syndrome. [PDF]

J Patient Rep Outcomes
Halpin SN, Hagenaar DA, Potter SN, van Wooning E, Gwaltney A, Mous SE, Wheeler AC.   +6 more
europepmc   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

<i>AIM</i> (Analyze-Interpret-Manage): A Novel NAPLEX-Aligned Analytical Assessment Framework for Measuring Individual and Team Critical Thinking Using Generative AI. [PDF]

Pharmacy (Basel)
Malhotra A.
europepmc   +1 more source