Results 121 to 130 of about 1,037,282 (261)

Enough?

Published online: 11 April 2025We respond to Aronow et al. (2025)’s paper arguing that randomized controlled trials (RCTs) are “enough,” while nonparametric identification in observational studies is not.
DIMMERY, Drew, MUNGER, Kevin
core   +1 more source

Comparative safety of direct oral anticoagulants and warfarinin venous thromboembolism: multicentre, population based, observational study

, 2018
OBJECTIVE To determine the safety of direct oral anticoagulant (DOAC) use compared with warfarin use for the treatment of venous thromboembolism. DESIGN Retrospective matched cohort study conducted between 1 January 2009 and 31 March 2016.
Lix, Lisa M., Wu, Cynthia, Ernst, Pierre, Yao, Shenzhen, Dahl, Matt, Durand, Madeleine, Dormuth, Colin R., Mahmoud, Salaheddin M., Paterson, J. Michael, Tamim, Hala, Renoux, Christel, Jun, Min, Hemmelgram, Brenda R.   +12 more
core   +1 more source

How Large Must an Associational Mean Difference Be to Support a Causal Effect?

Methodology
An observational study might support a causal claim if the association found cannot be explained by bias due to unconsidered confounders. This bias depends on how strongly the common predisposition, a summary of unconsidered confounders, is related to ...
Michael Höfler, Ekaterina Pronizius, Erin Buchanan   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Challenges in translating end points from trials to observational cohort studies in oncology

, 2016
Anne Gulbech Ording,1 Deirdre Cronin-Fenton,1 Vera Ehrenstein,1 Timothy L Lash,1,2 John Acquavella,1 Mikael Rørth,1 Henrik Toft Sørensen1 1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 2Department of&
Rørth M, Ording AG, Ehrenstein V, Lash TL, Acquavella J, Cronin-Fenton D, Sørensen HT   +6 more
core  

Association between serum vitamin D levels and the risk of diabetic retinopathy: a meta-analysis

Frontiers in Medicine
AimThis meta-analysis was conducted to quantitatively synthesize existing evidence on the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and diabetic retinopathy (DR).MethodsA systematic search of PubMed, Embase, the Web of Science, and ...
Yi Lan, Xinyi Ke
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Randomized controlled trials and real-world observational studies in evaluating cardiovascular safety of inhaled bronchodilator therapy in COPD

, 2016
Peter Kardos,1 Sally Worsley,2 Dave Singh,3 Miguel Román-Rodríguez,4 David E Newby,5 Hana Müllerová2 1Group Practice and Respiratory, Allergy and Sleep Unit, Red Cross Maingau Hospital, Frankfurt, Germany; 2GSK, Stockley Park ...
Worsley S, Müllerová H, Newby DE, Singh D, Kardos P, Román-Rodríguez M   +5 more
core  

Observational (cross-sectional and longitudinal) studies

, 2018
The chapter explores observational studies and their application in physical activity research with a particular focus on cross-sectional and longitudinal approaches. Considerations in the design and use of both types of studies are considered and the
Christopher Gidlow, Owens, Christopher S, Crone, Diane, David V.B. James, Gidlow, Christopher, James, David V, Diane Crone, Christopher S. Owens   +7 more
core   +1 more source

Ocular disorders during treatment with GLP-1 receptor agonists: a systematic review and meta-analysis of observational studies

Frontiers in Pharmacology
IntroductionDifferent observational studies have analyzed the effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on the risk of ocular adverse events (AEs).
Antonietta Anatriello, Antonietta Anatriello, Valerio Liguori, Valerio Liguori, Cecilia Cagnotta, Cecilia Cagnotta, Ciro Pentella, Ciro Pentella, Cristina Scavone, Cristina Scavone, Cristina Scavone, Annalisa Capuano, Annalisa Capuano, Barbara Rinaldi   +13 more
doaj   +1 more source