Results 101 to 110 of about 1,037,282 (261)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
How are missing data handled in observational time-to-event studies A systematic review.
, 2019 Missing data in covariates are known to result in biased estimates of association with the outcome and loss of power to detect associations. Missing data can also lead to other challenges in time-to-event analyses including the handling of time-varying ...
Carroll, Orlagh
core
Assessing observational studies of medical treatments
, 2005 Background Previous studies have assessed the validity of the observational study design by comparing results of studies using this design to results from randomized controlled trials.
Mary Charlton +13 more
core +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Non-Parametric Inference for the Effect of a Treatment on Survival Times with Application in the Health and Social Sciences [PDF]
In this paper we perform inference on the effect of a treatment on survival times in studies where the treatment assignment is not randomized and the assignment time is not known in advance.
de Luna, Xavier, Johansson, Per
core
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
, 2018 Objective: To quantify an association between acute kidney injury and use of high potency statins versus low potency statins. Design: Retrospective observational analysis of administrative databases, using nine population based cohort studies and meta ...
Levy, Adrian +9 more
core +1 more source
Pharmacoepidemiological studies: methodology and regulation
Качественная клиническая практика, 2018 This article describes the methodology of pharmacoepidemiological studies that help to research the efficacy and safety of drugs in real clinical practice at the level of a population or large groups of patients, promoting the rational and economically ...
D. Yu. Belousov, A. E. Cheberda
doaj
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source