Results 81 to 90 of about 1,037,282 (261)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Vitamin D status in women with pelvic floor disorders: A meta-analysis of observational studies

Journal of Mid-Life Health, 2019
The current evidence regarding the association between vitamin D status and pelvic floor disorder (PFD) are inconclusive. This meta-analysis was aimed to summarize existing data demonstrating the association between Vitamin D status and PFD using ...
Zinat Ghanbari, Maryam Karamali, Naghmeh Mirhosseini, Maryam Akbari, Reza Tabrizi, Kamran B Lankarani, Tahereh Eftekhar, Maryam Deldar Pesikhani, Shokoofeh Borzabadi, Zatollah Asemi   +9 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Apples and oranges: international comparisons of COVID-19 observational studies in ICUs

, 2020
Multiple observational cohorts describing the outcome of patients with COVID-19 from across the world have been published.1, 2, 3 Typically, these studies have reported regional or national cohorts and no two countries have had the same experience.
Millar, JE, Fraser, JF, Busse, R, Karagiannidis, C, McAuley, DF   +4 more
core   +1 more source

Real-world Cost per Responder Among Different Classes of Biologics for the Treatment of Psoriasis

Acta Dermato-Venereologica
Although biologics have revolutionized psoriasis treatment, they pose a significant burden on the healthcare budget. With the wide range of biologics available and the increasing number of biosimilars, insights into the real-world cost per responder (CPR)
Linda T.H. Godding, Marieke M.B. Seyger, Albert Duvetorp, Marisol E. Otero, Paul M. Ossenkoppele, Annet M. Oostveen, M. Birgitte Visch, Ella A.M. van der Voort, John E.M. Körver, Lizelotte J.M.T. Weppner-Parren, Maartje A.M. Berends, W. Peter Arnold, Sharon R.P. Dodemont, Astrid L.A. Kuijpers, Johannes M. Mommers, Femke M. Homan, Antoni H. Gostynski, Berit Velstra, Marloes M. Kleinpenning, Martijn B.A. van Doorn, Romy R.M.C. Keijsers, Else N. Kop, Inge M. Haeck, Judith H.J. Hendricksen-Roelofzen, Douwe Vellinga, Elke M.G.J. de Jong, Juul M.P.A. van den Reek   +26 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Characteristics of included studies–observational studies.

, 2018
Characteristics of included studies–observational studies.
Amir Zarrinpar (727123), Larry J. Prokop (5233949), Eduardo L. Grunvald (5233955), Antonio Facciorusso (3594857), Siddharth Singh (3173349), Abha G. Singh (5233952), Niels Vande Casteele (5233943), William J. Sandborn (5233946), Jeffrey R. Curtis (400737)   +8 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A systematic review of observational studies evaluating costs of adverse drug reactions

, 2016
Francisco Batel Marques,1,2 Ana Penedones,1,2 Diogo Mendes,1,2 Carlos Alves,1,2 1CHAD – Centre for Health Technology Assessment and Drug Research, AIBILI – Association for Innovation and Biomedical Research on Light and Image, 2School of ...
Penedones A, Alves C, Mendes D, Batel Marques F   +3 more
core