Results 231 to 240 of about 1,037,282 (261)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Suicidality risk of cancer caregivers: a systematic review and meta-analysis of observational studies. [PDF]

Ann Med
Zhu XY, Hu LY, Jin MY, Tung TH.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Maternal SARS-CoV-2 infection during pregnancy and child neurodevelopmental outcomes: A systematic review and meta-analysis of observational studies. [PDF]

Prev Med Rep
Whalley R, Primdal A, Hardie I, Xiao Z, Auyeung B.   +4 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A systematic review of observational studies on long-term air pollution exposure and epigenetic alterations in adults. [PDF]

J Glob Health
Yu L, Zhao Y, Chen W, Yu G, Miller MR, Li X, Theodoratou E.   +6 more
europepmc   +1 more source

Maternal macronutrient intake and gestational diabetes: systematic review of prospective observational studies and dose-response meta-analyses. [PDF]

BMC Med
Young CD, Garratt MG, Athukorala T, Perry TL, Ponnampalam AP, Crengle S, Peng M, Reynolds AN.   +7 more
europepmc   +1 more source

The value of observational studies in MDD research based on the example of trazodone once-a-day. [PDF]

Neurosci Appl
Krupa AJ.
europepmc   +1 more source

Prognostic Nutritional Index and Cancer Prognostic Outcomes: An Umbrella Review of Systematic Reviews and Meta-analyses of Observational Studies. [PDF]

Adv Nutr
Li ZT, Sun ML, Liu FH, Li Y, Bao RH, Jiang XF, Liu J, Lu Z, Yang Y, Yu Y, Zhao N, Chen Q, Fang Q, Feng ZF, Jia XX, Li DR, Luan M, Ma J, Wang Y, Xu YL, Yang D, Yang M, Yang R, Bai XL, Yang J, Li TG, Gong TT, Wu QJ.   +27 more
europepmc   +1 more source