Results 251 to 260 of about 1,473,678 (357)

Prescribed hormonal contraceptive use trends in the Estonian Biobank: A longitudinal observational study. [PDF]

PLoS Med
Džigurski J, Möls M, Läll K, Currant H, Eltermaa M, Estonian Biobank Research Team, Mägi R, Milani L, Laisk T.   +8 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Mode of delivery for confirmed macrosomia: a real-life multicentric observational study. [PDF]

BMC Pregnancy Childbirth
Mazard A, Desseauve D, Boulvain M, Atallah A, Massoud M, Gaucher L, de la Fourniere B.   +6 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Impact of immunosuppression on the incidence of ventilator-associated events: an observational study. [PDF]

BMC Anesthesiol
Vladimirov S, Klimenko I, Matiushkov N, Protsenko D, Sergeev D.   +4 more
europepmc   +1 more source

Effect of Metformin on Cancer Risk and Treatment Outcome of Prostate Cancer: A Meta-Analysis of Epidemiological Observational Studies

, 2014
Hongliang Yu, Li Yin, Xuesong Jiang, Xiujin Sun, Jing Wu, Hao Tian, Xianshu Gao, Xia He   +7 more
openalex   +2 more sources

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Impact of delayed elective urological surgery: A prospective observational study. [PDF]

BJUI Compass
Simunovic I, Zurl H, Altziebler J, Leitsmann C, Scheipner L, Mischinger J, Mangge A, Pohl K, Frank A, Weiss A, Bachmaier G, Ahyai S, Leitsmann M.   +12 more
europepmc   +1 more source

Homoeopathic management in depressive episodes: A prospective, unicentric, non-comparative, open-label observational study

, 2013
Praveen Oberai, Indira Balachandran, KR Janardhanan Nair, Anita Sharma, Vijay Pratap Singh, Vikram Singh, Chaturbhuja Nayak   +6 more
openalex   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source