Results 281 to 290 of about 1,473,678 (357)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Table 6_Examining the association between diet-related situational factor and dietary behavior: an observational study of diet-related situational factors in stroke patients during rehabilitation.docx

Weiying Zhong (20450062), Xi Pan (3080415), Jiaxuan Li (8894255), Yi Zhang (9093), Lei Chen (54296), Xueqi Sun (14564911), Zhi Wang (193655), Lan Xu (284324)   +7 more
openalex   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Temporal trends and future projections of fertility and birth rates in Georgia: a retrospective observational study. [PDF]

BMJ Open
Khachidze N, Anda EE, Manjavidze T, Nedberg IH, Sandøy IF, Rylander C.   +5 more
europepmc   +1 more source

Empirical piperacillin/tazobactam vs carbapenems to treat bloodstream infections due to ESBL enterobacterales: a propensity score-matched observational study conducted in an emergency department in Northern Italy

Capsoni, Nicolò, Bettina, Marco, Bellone, Beatrice, Bossi, Ilaria Emanuela, Cantù, Lisa, Rossmann, Marta, Scarnera, Marida, Serrai, Irene, Vergani, Silvia, Privitera, Daniele, Bernasconi, Davide Paolo, Puoti, Massimo, Merli, Marco, Galbiati, Filippo, Costantino, Giorgio, Bombelli, Michele   +15 more
openalex   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Unveiling the Weapons of Superbug Pseudomonas: A Cross-sectional Observational Study on Virulence Factors and Antimicrobial Resistance of a Lurking Pathogen

Smita Vijayraj Mohod, Ravindra K Khadse, Sonal Chavan, Sharmila Raut   +3 more
openalex   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Off-Label Manipulation of Paediatric Medication Remains a Challenge in Clinical Practice: An Observational Study. [PDF]

Acta Paediatr
Hamre Svendsen R, Andersen JKN, Kälvemark Sporrong S, Andersson Y, Tho I.   +4 more
europepmc   +1 more source

Psychometric properties of the hematopoietic cell transplantation frailty scale: A prospective observational study. [PDF]

Hematol Transfus Cell Ther
Lorca LA, Puga Larrain B, Gonzalez Valdivia I, Molina J, Leao Ribeiro I.   +4 more
europepmc   +1 more source