Results 51 to 60 of about 49,584,610 (301)

Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study

The Lancet Rheumatology, 2020
Background Tocilizumab, a monoclonal antibody directed against the interleukin-6 receptor, has been proposed to mitigate the cytokine storm syndrome associated with severe COVID-19. We aimed to investigate the association between tocilizumab exposure and
N. Biran, A. Ip, Jaeil Ahn, Ronaldo C. Go, Shuqi Wang, S. Mathura, Brittany A Sinclaire, Urszula Bednarz, M. Marafelias, E. Hansen, D. Siegel, A. Goy, A. Pecora, I. Sawczuk, L. Koniaris, Micky Simwenyi, D. Varga, Lisa K. Tank, A. Stein, V. Allusson, G. S. Lin, W. Oser, Roman A. Tuma, J. Reichman, L. Brusco, Kim Carpenter, E. Costanzo, V. Vivona, S. Goldberg   +28 more
semanticscholar   +1 more source

Results of the Childhood Cancer and Leukaemia Group's United Kingdom Relapsed Wilms Tumour Trial

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The United Kingdom relapsed Wilms tumour (UKW‐R) trial aimed to improve the historically low survival rates after relapse of Wilms tumour (WT) through a prospective national risk‐stratified protocol. The trial also evaluated efficacy and toxicity of high‐dose melphalan.
Sucheta J. Vaidya, Veronica Moroz, Juliet Hale, Vesna Pavasovic, Rachel Hobson, Patricia Sartori, Daniel Saunders, Mark Powis, Gordan M. Vujanic, Stephen Baker, Kathy Pritchard‐Jones   +10 more
wiley   +1 more source

Effects of sevoflurane anesthesia and abdominal surgery on the systemic metabolome: a prospective observational study

BMC Anesthesiology, 2021
Background Metabolic status can be impacted by general anesthesia and surgery. However, the exact effects of general anesthesia and surgery on systemic metabolome remain unclear, which might contribute to postoperative outcomes.
Yiyong Wei, Donghang Zhang, Jin Liu, Mengchan Ou, Peng Liang, Yunxia Zuo, Cheng Zhou   +6 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Efficacy and tolerability of perampanel: a Chinese real-world observational study in epilepsy

Frontiers in Neurology
PurposeTo investigate whether there exists a statistically significant distinction between the effectiveness and tolerance of perampanel (PER) and the number of antiseizure medications (ASMs) that were tried prior to administering PER.MethodA prospective,
Ya Zeng, Xintong Wu
doaj   +1 more source

Malnutrition and clinical outcome in urological patients

European Journal of Medical Research, 2011
Introduction In a previous study we evaluated the risk for malnutrition among urological patients in a German university hospital. There are published different studies in other surgical fields that could show a correlation between malnutrition and ...
Karl A, Staehler M, Bauer R, Tritschler S, Hocaoglu Y, Buchner A, Hoffmann J, Kuppinger D, Stief C, Rittler P   +9 more
doaj   +1 more source

Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy, Elizabeth L. Seashore, W. Susan Cheng, Shondra Clay, Jessica A. Casas, Jennifer H. Foster   +5 more
wiley   +1 more source

Vascular skin symptoms in COVID‐19: a French observational study

Journal of the European Academy of Dermatology and Venereology, 2020
Coronavirus 19 (COVID-19) was declared as a pandemic viral infection by the World Health organization on March 11th 2020. Usual clinical manifestations of COVID-19 infection include fever, fatigue, myalgia, headache, diarrhea, dry cough, dyspnea that may
J. Bouaziz, T. Duong, M. Jachiet, C. Velter, P. Lestang, C. Cassius, A. Arsouze, E. Trong, M. Bagot, E. Bégon, L. Sulimovic, M. Rybojad   +11 more
semanticscholar   +1 more source

Criterion‐Related Validity of the Neuropsychological Quick Assessment for Screening Cognitive, Motor, and Behavioral Impairments in Patients With Pediatric Brain Tumors: An Observational Pilot Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neuropsychological complications may impair the qualitative prognosis of patients with pediatric brain tumors. However, multifaceted evaluations cannot be conducted in all patients because they are time consuming and burdensome for patients.
Ami Tabata, Keita Ueda, Tsukasa Ueno, Katsutsugu Umeda, Kentaro Ueno, Kanade Tanaka, Noyuri Nishida, Rie Yamawaki, Megumi Nukui, Yoshiki Arakawa   +9 more
wiley   +1 more source

Cluster Formation in a Filamentary Cloud: The Case of the Stellar Cluster NGC 2316

The Astronomical Journal
We present a multiwavelength analysis of the star cluster NGC 2316 and its surroundings. We estimated the physical parameters of the NGC 2316 cluster, including its shape (elongated), size ( R _cluster = 0.4 pc), distance (1.3 ± 0.3 kpc), and minimum ...
Saurabh Sharma, Aayushi Verma, Kshitiz Mallick, Lokesh K. Dewangan, Harmeen Kaur, Ram Kesh Yadav, Neelam Panwar, Devendra K. Ojha, Tarak Chand, Mamta Agarwal   +9 more
doaj   +1 more source