Results 91 to 100 of about 256,970 (318)
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Uniformly expanding vacuum: a possible interpretation of the dark energy
, 2016 Following the spirit of the equivalence principle, we take a step further to recognize the free fall of the observer as a method to eliminate causes that would lead the perceived vacuum to change its original state.
Huang, Peng, Yuan, Fang-Fang
core +1 more source
The Smoothness of Physical Observables
, 2009 The Garvey-Kelson (GK) relations are powerful algebraic expressions connecting the masses of neighboring atomic nuclei and derived under reasonable physical assumptions. In this contribution we show that these relations are even more general than originally assumed as their validity is conditioned by the smoothness of the underlying nuclear mass ...
Piekarewicz, J. +3 more
openaire +2 more sources
Interpreting Observations of Physical Systems [PDF]
IEEE Transactions on Systems, Man, and Cybernetics, 1987 An unsolved problem in creating diagnostic expert systems is generating a qualitative understanding of how the system is behaving from raw data, especially numerical data taken across time. Yet automating this critical step is necessary for building the next generation of expert systems.
openaire +3 more sources
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Quantum Physics and the Existence of God
ReligionsInterpretations of quantum physics are shown to presuppose the reality of consciousness. But if a minimal realism about the external world is true, then the consciousness presupposed by quantum reality cannot be only that of the scientific observer ...
Stephen Priest
doaj +1 more source
Discrete Symmetries Underlying Some Continuous Ones: Two Examples From Gravity And Particle Physics [PDF]
, 2002 Two examples, not connected at present, from author's papers (Nuovo Cim., 1992, v.105A, p.77 [hep-th/0207210] and GRG, 1999, v.31, p.1431 [gr-qc/0207017]) are considered here in which a physical model has discrete symmetries and additional non-observable
Ivanov, Michael A.
core +1 more source
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
Initial states and infrared physics in locally de Sitter spacetime
, 2012 The long wavelength physics in a de Sitter region depends on the initial quantum state. While such long wavelength physics is under control for massive fields near the Hartle-Hawking vacuum state, such initial states make unnatural assumptions about ...
A. Polyakov +6 more
core +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source