Results 101 to 110 of about 5,120,899 (402)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Reliability and agreement of root length measurements during orthodontic treatment in images from different CBCT machines using multiplanar reconstruction

Biomaterial Investigations in Dentistry
Objectives: To assess inter- and intrarater reliability and agreement for measurements of root lengths using multiplanar reconstruction (MPR) in cone beam computed tomography (CBCT) examinations.
Kristina Johansson, Liselotte Paulsson, Helena Christell   +2 more
doaj   +1 more source

On Measuring the Variation of High Energy Cut-off in Active Galactic Nuclei [PDF]

, 2018
The variation in the high energy cut-off E_c in active galactic nuclei uniquely probes the corona physics. In this work we show that the ratio of two NuSTAR spectra (in analogy to difference imaging technique widely used in astronomy) is uniquely useful in studying E_c variations.
arxiv   +1 more source

Attracting Interest: Dynamic Displays of Proceptivity Increase the Attractiveness of Men and Women [PDF]

, 2008
Proceptive signals may influence judgments of opposite-sex attractiveness because these signals indicate high mate quality and/or non-threatening behavior but they may also signal high probable rate of return for mating effort.
Clark, AP
core   +2 more sources

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

The potential impact of CT-MRI matching on tumor volume delineation in advanced head and neck cancer [PDF]

, 1997
To study the potential impact of the combined use of CT and MRI scans on the Gross Tumor Volume (GTV) estimation and interobserver variation. Four observers outlined the GTV in six patients with advanced head and neck cancer on CT, axial MRI, and coronal
Bartelink, H, de Ru, V, Keus, R, Koops, W, Lebesque, J V, Muller, S, Pameijer, F A, Rasch, C, Touw, A, van Herk, M, Van Herk, Marcel   +10 more
core   +3 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Blazar Anti-Sequence of Spectral Variation within individual Blazars: Cases for Mrk 501 and 3C 279

, 2013
The jet properties of Mrk 501 and 3C 279 are derived by fitting the broadband spectral energy distributions with the lepton models. The derived gamma_b (the break Lorenz factor of the electron distribution) are 10^4-10^6 for Mrk 501 and 200~600 for 3C ...
Liang, En-Wei, Zhang, Jin, Zhang, Shuang-Nan   +2 more
core   +1 more source

A new method for improved standardisation in three-dimensional computed tomography cephalometry [PDF]

, 2010
Interest for three-dimensional computed tomography cephalometry has risen over the last two decades. Current methods commonly rely on the examiner to manually point-pick the landmarks and/or orientate the skull. In this study, a new approach is presented,
Braem, Marc, Brijs, Guy, De Beule, Matthieu, Okkerse, Walter, Van Cauter, Sofie, Verhegghe, Benedict   +5 more
core   +2 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source