Results 141 to 150 of about 5,120,899 (402)

Inter-observer variation of target volume delineation for CT-guided cervical cancer brachytherapy. [PDF]

J Contemp Brachytherapy, 2023
Elmali A, Biltekin F, Sari SY, Gultekin M, Yuce D, Yildiz F.   +5 more
europepmc   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

The impact of inter-observer variation in delineation on robustness of radiomics features in non-small cell lung cancer. [PDF]

Sci Rep, 2022
Kothari G, Woon B, Patrick CJ, Korte J, Wee L, Hanna GG, Kron T, Hardcastle N, Siva S.   +8 more
europepmc   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Diagnostic agreement between radiologists, dentists and dental students for radiographic detection of approximal caries.

Journal of Oral Research, 2015
Aim: To assess intraobserver and interobserver agreement for radiographic detection of approximal caries among radiologists, dentists and senior dental students.
Sergio E Uribe, Felipe Lara-Abarzúa, Nicolás Ruiz-Miranda, Katherine Bravo-Gajardo, Daniela Huichaman   +4 more
doaj   +1 more source

iCare® Home vs Goldmann applanation tonometry: Agreement of methods and comparison of inter-observer variation at a tertiary eye centre. [PDF]

Eur J Ophthalmol, 2023
Quérat L, Chen E.
europepmc   +1 more source

Time Variations in Elemental Abundances in Solar Energetic Particle Events [PDF]

, 2001
The Solar Isotope Spectrometer (SIS) on-board the Advanced Composition Explorer has a large collection power and high telemetry rate, making it possible to study elemental abundances in large solar energetic particle (SEP) events as a function of time ...
Christian, E. R., Cohen, C. M. S., Cummings, A. C., Leske, R. A., Mewaldt, R. A., Slocum, P. L., St. Cyr, O. C., Stone, E. C., von Rosenvinge, T. T., Wiedenbeck, M. E.   +9 more
core  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

VAE-Var: Variational-Autoencoder-Enhanced Variational Assimilation [PDF]

arXiv
Data assimilation refers to a set of algorithms designed to compute the optimal estimate of a system's state by refining the prior prediction (known as background states) using observed data. Variational assimilation methods rely on the maximum likelihood approach to formulate a variational cost, with the optimal state estimate derived by minimizing ...
arxiv