Results 151 to 160 of about 4,762,697 (358)

Transformer-Based HER2 Scoring in Breast Cancer: Comparative Performance of a Foundation and a Lightweight Model

Diagnostics
Background/Objectives: Human epidermal growth factor 2 (HER2) scoring is critical for modern breast cancer therapies, especially with emerging indications of antibody–drug conjugates for HER2-low tumors.
Yeh-Han Wang, Min-Hsiang Chang, Hsin-Hsiu Tsai, Chun-Jui Chien, Jian-Chiao Wang   +4 more
doaj   +1 more source

OC10.02: Inter‐observer variation in diagnosing adenomyosis using two‐ and three‐dimensional transvaginal ultrasound [PDF]

, 2013
C Rasmussen, Margit Dueholm, Niels Uldbjerg   +2 more
openalex   +1 more source

Intra- and inter-observer variation and accuracy using different shear wave elastography methods to assess circumscribed objects - a phantom study.

Medical ultrasonography, 2017
G. Seliger, K. Chaoui, C. Kunze, Y. Dridi, K. Jenderka, A. Wienke, M. Tchirikov   +6 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Inter-observer variations in bite marks analysis

, 2021
Pratik Tarvadi, N. N. Kishore, Shahnavaz Manipady, Mahabalesh Shetty   +3 more
openalex   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Atmospheric Variations as observed by IceCube

, 2010
4 pages, Proceedings of the 31st ICRC, Lodz, Poland, July ...
Tilav, Serap, Desiati, Paolo, Kuwabara, Takao, Rocco, Dominick, Rothmaier, Florian, Simmons, Matt, Wissing, Henrike   +6 more
openaire   +2 more sources

VARIATION OF THE FUNDAMENTAL CONSTANTS: THEORY AND OBSERVATIONS

International Journal of Modern Physics A, 2007
Review of recent works devoted to the variation of the fine structure constant α, strong interaction and fundamental masses (Higgs vacuum) is presented. The results from Big Bang nucleosynthesis, quasar absorption spectra, and Oklo natural nuclear reactor data give us the space-time variation on the Universe lifetime scale.
openaire   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source